UNIGE document Scientific Article
previous document  unige:8949  next document
add to browser collection
Title

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex

Authors
Palma, Veronica
Published in Development. 2004, vol. 131, no. 2, p. 337-345
Abstract Stem cells are crucial for normal development and homeostasis, and their misbehavior may be related to the origin of cancer. Progress in these areas has been difficult because the mechanisms regulating stem cell lineages are not well understood. Here, we have investigated the role of the SHH-GLI pathway in the developing mouse neocortex. The results show that SHH signaling endogenously regulates the number of embryonic and postnatal mouse neocortical cells with stem cell properties, and controls precursor proliferation in a concentration-dependent manner in cooperation with EGF signaling. These findings identify a crucial mechanism for the regulation of the number of cells with stem cell properties that is unexpectedly conserved in different stem cell niches.
Keywords AnimalsCell DivisionDNA-Binding Proteins/genetics/ metabolismEpidermal Growth Factor/metabolismGene Expression Regulation, DevelopmentalHedgehog ProteinsKruppel-Like Transcription FactorsMiceMice, Inbred C57BLMice, KnockoutMice, Mutant StrainsNeocortex/ cytology/ embryology/metabolismNerve Tissue ProteinsPhenotypeSignal TransductionStem Cells/ cytology/metabolismTrans-Activators/genetics/ metabolismTranscription Factors/genetics/ metabolism
Identifiers
PMID: 14681189
Full text
Article - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://dev.biologists.org/content/131/2/337.full.pdf
Structures
Citation
(ISO format)
PALMA, Veronica, RUIZ ALTABA, Ariel. Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex. In: Development, 2004, vol. 131, n° 2, p. 337-345. https://archive-ouverte.unige.ch/unige:8949

214 hits

0 download

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :