Scientific article
Open access

Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study

Published inJournal of the American Society of Nephrology, vol. 26, no. 6, p. 1415-1425
Publication date2015

Arginine vasopressin (AVP) has a key role in osmoregulation by facilitating water transport in the collecting duct. Recent evidence suggests that AVP may have additional effects on renal function and favor cyst growth in polycystic kidney disease. Whether AVP also affects kidney structure in the general population is unknown. We analyzed the association of copeptin, an established surrogate for AVP, with parameters of renal function and morphology in a multicentric population-based cohort. Participants from families of European ancestry were randomly selected in three Swiss cities. We used linear multilevel regression analysis to explore the association of copeptin with renal function parameters as well as kidney length and the presence of simple renal cysts assessed by ultrasound examination. Copeptin levels were log-transformed. The 529 women and 481 men had median copeptin levels of 3.0 and 5.2 pmol/L, respectively (P<0.001). In multivariable analyses, the copeptin level was associated inversely with eGFR (β=-2.1; 95% confidence interval [95% CI], -3.3 to -0.8; P=0.002) and kidney length (β=-1.2; 95% CI, -1.9 to -0.4; P=0.003) but positively with 24-hour urinary albumin excretion (β=0.11; 95% CI, 0.01 to 0.20; P=0.03) and urine osmolality (β=0.08; 95% CI, 0.05 to 0.10; P<0.001). A positive association was found between the copeptin level and the presence of renal cysts (odds ratio, 1.6; 95% CI, 1.1 to 2.4; P=0.02). These results suggest that AVP has a pleiotropic role in renal function and may favor the development of simple renal cysts.

  • Adult
  • Analysis of Variance
  • Arginine Vasopressin/metabolism
  • Biomarkers/metabolism
  • Confidence Intervals
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate/physiology
  • Glycopeptides/metabolism
  • Humans
  • Kidney/physiopathology
  • Kidney Function Tests
  • Linear Models
  • Male
  • Middle Aged
  • Monitoring, Physiologic/methods
  • Polycystic Kidney Diseases/metabolism/physiopathology
  • Reference Values
  • Retrospective Studies
  • Severity of Illness Index
  • Switzerland
  • Urinalysis
Citation (ISO format)
PONTE, Belen et al. Copeptin is associated with kidney length, renal function, and prevalence of simple cysts in a population-based study. In: Journal of the American Society of Nephrology, 2015, vol. 26, n° 6, p. 1415–1425. doi: 10.1681/ASN.2014030260
Main files (1)
Article (Published version)
ISSN of the journal1046-6673

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