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Title

Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor

Authors
Davis, J. G.
Berger, M.
Published in Biochemical Journal. 1979, vol. 182, no. 1, p. 249-251
Abstract We have previously observed that, on subcutaneous administration, a significant proportion of insulin is degraded at the site of injection. The present paper reports that the degradative activity of slices of rat adipose tissue can be inhibited in vitro by ophthalmic acid, a natural analogue of glutathione, and by bovine pancreatic proteinase inhibitor, whereas it is increased by the addition of reduced glutathione.
Keywords Adipose Tissue/drug effects/ metabolismAnimalsAprotinin/ pharmacologyDepression, ChemicalGlutathione/analogs & derivativesInsulin/ metabolismOligopeptides/ pharmacologyRats
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PMID: 315228
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OFFORD, Robin Ewart et al. Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor. In: Biochemical Journal, 1979, vol. 182, n° 1, p. 249-251. https://archive-ouverte.unige.ch/unige:8943

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Deposited on : 2010-07-12

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