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Scientific article
English

Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor

Published inBiochemical journal, vol. 182, no. 1, p. 249-251
Publication date1979
Abstract

We have previously observed that, on subcutaneous administration, a significant proportion of insulin is degraded at the site of injection. The present paper reports that the degradative activity of slices of rat adipose tissue can be inhibited in vitro by ophthalmic acid, a natural analogue of glutathione, and by bovine pancreatic proteinase inhibitor, whereas it is increased by the addition of reduced glutathione.

Keywords
  • Adipose Tissue/drug effects/ metabolism
  • Animals
  • Aprotinin/ pharmacology
  • Depression, Chemical
  • Glutathione/analogs & derivatives
  • Insulin/ metabolism
  • Oligopeptides/ pharmacology
  • Rats
Citation (ISO format)
OFFORD, Robin Ewart et al. Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor. In: Biochemical journal, 1979, vol. 182, n° 1, p. 249–251. doi: 10.1042/bj1820249
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ISSN of the journal0264-6021
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