Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor

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Title		Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor
Authors		Offord, Robin Ewart Philippe, Jacques Davis, J. G. Halban, Philippe A. Berger, M.
Published in		Biochemical Journal. 1979, vol. 182, no. 1, p. 249-251
Abstract		We have previously observed that, on subcutaneous administration, a significant proportion of insulin is degraded at the site of injection. The present paper reports that the degradative activity of slices of rat adipose tissue can be inhibited in vitro by ophthalmic acid, a natural analogue of glutathione, and by bovine pancreatic proteinase inhibitor, whereas it is increased by the addition of reduced glutathione.
Keywords		Adipose Tissue/drug effects/ metabolism — Animals — Aprotinin/ pharmacology — Depression, Chemical — Glutathione/analogs & derivatives — Insulin/ metabolism — Oligopeptides/ pharmacology — Rats
Identifiers		DOI: 10.1042/bj1820249 PMID: 315228
Full text		Article - Limited access to UNIGE Other version: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1161257/pdf/biochemj00456-0242.pdf
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Citation (ISO format)		OFFORD, Robin Ewart et al. Inhibition of degradation of insulin by ophthalamic acid and by a bovine pancreatic proteinase inhibitor. In: Biochemical Journal, 1979, vol. 182, n° 1, p. 249-251. https://archive-ouverte.unige.ch/unige:8943