Complementary pathways in mammalian female sex determination

Nef, Serge; Vassalli, Jean-Dominique

doi:10.1186/jbiol173

Scientific article

English

Complementary pathways in mammalian female sex determination

ContributorsNef, Serge

; Vassalli, Jean-Dominique

Published inJournal of biology, vol. 8, no. 8, 74

Publication date2009

Abstract

In mammals, the sex of the embryo is determined by the fate of the gonad. Recent papers, including one in BMC Developmental Biology, shed light on the molecular regulation of ovarian development and suggest that the R-spondin1/Wnt4/beta-catenin pathway and the Foxl2 transcription factor act in a complementary manner to promote ovarian fate and to repress testicular development.

Keywords

Animals
Embryo, Mammalian/embryology/physiology
Female
Forkhead Transcription Factors/metabolism
Gene Expression Regulation, Developmental
Humans
Male
Ovary/ embryology/physiology
Sex Determination (Genetics)
Signal Transduction
Thrombospondins/metabolism
Wnt Proteins/metabolism
Beta Catenin/metabolism

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

NEF, Serge, VASSALLI, Jean-Dominique. Complementary pathways in mammalian female sex determination. In: Journal of biology, 2009, vol. 8, n° 8, p. 74. doi: 10.1186/jbiol173

Article

CC BY

Identifiers

PID : unige:8938
DOI : 10.1186/jbiol173
PMID : 19735582

Commercial URLhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776915/pdf/jbiol173.pdf

ISSN of the journal1475-4924

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Complementary pathways in mammalian female sex determination

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