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Scientific article
Open access
English

Complementary pathways in mammalian female sex determination

Published inJournal of biology, vol. 8, no. 8, 74
Publication date2009
Abstract

In mammals, the sex of the embryo is determined by the fate of the gonad. Recent papers, including one in BMC Developmental Biology, shed light on the molecular regulation of ovarian development and suggest that the R-spondin1/Wnt4/beta-catenin pathway and the Foxl2 transcription factor act in a complementary manner to promote ovarian fate and to repress testicular development.

Keywords
  • Animals
  • Embryo, Mammalian/embryology/physiology
  • Female
  • Forkhead Transcription Factors/metabolism
  • Gene Expression Regulation, Developmental
  • Humans
  • Male
  • Ovary/ embryology/physiology
  • Sex Determination (Genetics)
  • Signal Transduction
  • Thrombospondins/metabolism
  • Wnt Proteins/metabolism
  • Beta Catenin/metabolism
Citation (ISO format)
NEF, Serge, VASSALLI, Jean-Dominique. Complementary pathways in mammalian female sex determination. In: Journal of biology, 2009, vol. 8, n° 8, p. 74. doi: 10.1186/jbiol173
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Identifiers
ISSN of the journal1475-4924
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