UNIGE document Scientific Article
previous document  unige:89207  next document
add to browser collection
Title

VTA Projection Neurons Releasing GABA and Glutamate in the Dentate Gyrus

Authors
Published in eNeuro. 2016, vol. 3, no. 4
Abstract Both dopamine and nondopamine neurons from the ventral tegmental area (VTA) project to a variety of brain regions. Here we examine nondopaminergic neurons in the mouse VTA that send long-range projections to the hippocampus. Using a combination of retrograde tracers, optogenetic tools, and electrophysiological recordings, we show that VTA GABAergic axons make synaptic contacts in the granule cell layer of the dentate gyrus, where we can elicit small postsynaptic currents. Surprisingly, the currents displayed a partial sensitivity to both bicuculline and NBQX, suggesting that these mesohippocampal neurons corelease both GABA and glutamate. Finally, we show that this projection is functional in vivo and its stimulation reduces granule cell-firing rates under anesthesia. Altogether, the present results describe a novel connection between GABA and glutamate coreleasing of cells of the VTA and the dentate gyrus. This connection could be relevant for a variety of functions, including reward-related memory and neurogenesis.
Identifiers
PMID: 27648470
Full text
Article (Published version) (3.4 MB) - public document Free access
Structures
Research group Mécanismes cellulaires de la dépendance et de l'addiction (520)
Citation
(ISO format)
NTAMATI RWAKA, Niels, LUSCHER, Christian. VTA Projection Neurons Releasing GABA and Glutamate in the Dentate Gyrus. In: eNeuro, 2016, vol. 3, n° 4. https://archive-ouverte.unige.ch/unige:89207

45 hits

23 downloads

Update

Deposited on : 2016-11-21

Export document
Format :
Citation style :