Scientific article
Open access

VTA Projection Neurons Releasing GABA and Glutamate in the Dentate Gyrus

Published inENeuro, vol. 3, no. 4
Publication date2016

Both dopamine and nondopamine neurons from the ventral tegmental area (VTA) project to a variety of brain regions. Here we examine nondopaminergic neurons in the mouse VTA that send long-range projections to the hippocampus. Using a combination of retrograde tracers, optogenetic tools, and electrophysiological recordings, we show that VTA GABAergic axons make synaptic contacts in the granule cell layer of the dentate gyrus, where we can elicit small postsynaptic currents. Surprisingly, the currents displayed a partial sensitivity to both bicuculline and NBQX, suggesting that these mesohippocampal neurons corelease both GABA and glutamate. Finally, we show that this projection is functional in vivo and its stimulation reduces granule cell-firing rates under anesthesia. Altogether, the present results describe a novel connection between GABA and glutamate coreleasing of cells of the VTA and the dentate gyrus. This connection could be relevant for a variety of functions, including reward-related memory and neurogenesis.

Citation (ISO format)
NTAMATI RWAKA, Niels, LUSCHER, Christian. VTA Projection Neurons Releasing GABA and Glutamate in the Dentate Gyrus. In: ENeuro, 2016, vol. 3, n° 4. doi: 10.1523/ENEURO.0137-16.2016
Main files (1)
Article (Published version)
ISSN of the journal2373-2822

Technical informations

Creation10/19/2016 10:17:00 AM
First validation10/19/2016 10:17:00 AM
Update time03/15/2023 12:58:24 AM
Status update03/15/2023 12:58:24 AM
Last indexation01/16/2024 10:21:18 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack