Scientific article

The resolution of the genetics of gene expression

Published inHuman molecular genetics, vol. 18, no. R2, p. R211-215
Publication date2009

Understanding the influence of genetics on the molecular mechanisms underpinning human phenotypic diversity is fundamental to being able to predict health outcomes and treat disease. To interrogate the role of genetics on cellular state and function, gene expression has been extensively used. Past and present studies have highlighted important patterns of heritability, population differentiation and tissue-specificity in gene expression. Current and future studies are taking advantage of systems biology-based approaches and advances in sequencing technology: new methodology aims to translate regulatory networks to enrich pathways responsible for disease etiology and 2nd generation sequencing now offers single-molecular resolution of the transcriptome providing unprecedented information on the structural and genetic characteristics of gene expression. Such advances are leading to a future where rich cellular phenotypes will facilitate understanding of the transmission of genetic effect from the gene to organism.

  • Animals
  • Disease/genetics
  • Environment
  • Gene Expression Regulation/ genetics
  • Gene Regulatory Networks/genetics
  • Humans
  • Organ Specificity/genetics
  • Principal Component Analysis
Citation (ISO format)
MONTGOMERY, S. B., DERMITZAKIS, Emmanouil. The resolution of the genetics of gene expression. In: Human molecular genetics, 2009, vol. 18, n° R2, p. R211–215. doi: 10.1093/hmg/ddp400
Main files (1)
ISSN of the journal0964-6906

Technical informations

Creation07/12/2010 11:59:11 AM
First validation07/12/2010 11:59:11 AM
Update time03/14/2023 3:52:07 PM
Status update03/14/2023 3:52:07 PM
Last indexation02/12/2024 6:54:48 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack