Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3

Sari, Katalin

doi:10.13097/archive-ouverte/unige:88980

Doctoral thesis

English

Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3

ContributorsSari, Katalin

DirectorsHoltmaat, Anthony

; Muller, Dominique

Defense date2016-06-22

Abstract

The importance of our research consists of the identification of novel pathophysiological mechanisms that may underlie PAK3-related familial cases of mental retardation. The finding that PAK3 gene could affect synaptic protein PSD-95 dynamics and also influence local protein synthesis by acting on the PI3K/AKT/mTOR signaling pathway may allude to pharmacological therapies.

Keywords

Cognitive disability
PAK3
PSD-95
PI3K/AKT/mTOR signaling

NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne

Affiliation entities

Funding

Autre - SyMBaD program via ITN Marie Curie, Grant Agreement n° 238608–7th Framework Programme
Autre - Swiss National Centre of Competence in Research (NCCR) "SYNAPSY" financed by the Swiss National Science Foundation (n° 51AU40_125759); Swiss National Science foundation grant 310030B_144080 to D.M.

Citation (ISO format)

SARI, Katalin. Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3. Doctoral Thesis, 2016. doi: 10.13097/archive-ouverte/unige:88980

Thesis

Identifiers

PID : unige:88980
DOI : 10.13097/archive-ouverte/unige:88980
URN : urn:nbn:ch:unige-889800
Thesis number : Neur. 164

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Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3

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