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Doctoral thesis
English

Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3

ContributorsSari, Katalin
Defense date2016-06-22
Abstract

The importance of our research consists of the identification of novel pathophysiological mechanisms that may underlie PAK3-related familial cases of mental retardation. The finding that PAK3 gene could affect synaptic protein PSD-95 dynamics and also influence local protein synthesis by acting on the PI3K/AKT/mTOR signaling pathway may allude to pharmacological therapies.

eng
Keywords
  • Cognitive disability
  • PAK3
  • PSD-95
  • PI3K/AKT/mTOR signaling
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
Funding
  • Autre - SyMBaD program via ITN Marie Curie, Grant Agreement n° 238608–7th Framework Programme
  • Autre - Swiss National Centre of Competence in Research (NCCR) "SYNAPSY" financed by the Swiss National Science Foundation (n° 51AU40_125759); Swiss National Science foundation grant 310030B_144080 to D.M.
Citation (ISO format)
SARI, Katalin. Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3. 2016. doi: 10.13097/archive-ouverte/unige:88980
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Creation09/04/2016 8:17:00 AM
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