Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3

Diplôme Thèse Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3 eng 2016-06-22 author Sari Katalin 736787 director Holtmaat Anthony 0000-0002-7577-0769 661031 director Muller Dominique 26488 10.13097/archive-ouverte/unige:88980 urn:nbn:ch:unige-889800 Neur. 164 The importance of our research consists of the identification of novel pathophysiological mechanisms that may underlie PAK3-related familial cases of mental retardation. The finding that PAK3 gene could affect synaptic protein PSD-95 dynamics and also influence local protein synthesis by acting on the PI3K/AKT/mTOR signaling pathway may allude to pharmacological therapies. Diplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne Cognitive disability PAK3 PSD-95 PI3K/AKT/mTOR signaling Dewey 500 Dewey 616.8 Autre SyMBaD program via ITN Marie Curie, Grant Agreement n° 238608–7th Framework Programme Autre Swiss National Centre of Competence in Research (NCCR) "SYNAPSY" financed by the Swiss National Science Foundation (n° 51AU40_125759); Swiss National Science foundation grant 310030B_144080 to D.M. 2 Faculté des sciences 1 53 Département de neurosciences fondamentales 21A false 9f2016ee-545b-4996-b247-bf10068d8859 Thesis Private Sari.Katalin.correctedthesis.toprint.150ppi.v2.pdf 12224191 application/pdf 9b49dfc1ffc1d216cb1b12e1b0f6f4c032e8ccd9f4dc282a18fe6acd6f12a13e closedAccess Faculté des sciences Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Mechanisms underlying the synaptic alterations produced by the cognitive disability protein PAK3				2016	803	0

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Sari, Katalin