UNIGE document Scientific Article
previous document  unige:88892  next document
add to browser collection

Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model

Mesquita, Ana
Dominguez, Eunice
Muñoz-Braceras, Sandra
Nuñez-Corcuera, Beatriz
Phillips, Ben A
Tábara, Luis C
Xiong, Qiuhong
show hidden authors show all authors [1 - 15]
Published in Autophagy. 2017, vol. 13, no. 1, p. 24-40
Abstract Autophagy is a fast-moving field with an enormous impact on human health and disease. Understanding the complexity of the mechanism and regulation of this process often benefits from the use of simple experimental models such as the social amoeba Dictyostelium discoideum. Since the publication of the first review describing the potential of D. discoideum in autophagy, significant advances have been made that demonstrate both the experimental advantages and interest in using this model. Since our previous review, research in D. discoideum has shed light on the mechanisms that regulate autophagosome formation and contributed significantly to the study of autophagy-related pathologies. Here, we review these advances, as well as the current techniques to monitor autophagy in D. discoideum. The comprehensive bioinformatics search of autophagic proteins that was a substantial part of the previous review has not been revisited here except for those aspects that challenged previous predictions such as the composition of the Atg1 complex. In recent years our understanding of, and ability to investigate, autophagy in D. discoideum has evolved significantly and will surely enable and accelerate future research using this model.
PMID: 27715405
Full text
Article (Published version) (1.3 MB) - public document Free access
Research group Groupe Soldati
(ISO format)
MESQUITA, Ana et al. Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model. In: Autophagy, 2017, vol. 13, n° 1, p. 24-40. doi: 10.1080/15548627.2016.1226737 https://archive-ouverte.unige.ch/unige:88892

1473 hits



Deposited on : 2016-11-14

Export document
Format :
Citation style :