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Title

Gap junction development is correlated with insulin content in the pancreatic B cell

Authors
Renold, A. E.
Published in Science. 1980, vol. 209, no. 4460, p. 1026-1028
Abstract The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.
Keywords AnimalsCell Communication/drug effectsFemaleFreeze FracturingGlyburide/ pharmacologyInsulin/ metabolismIntercellular Junctions/drug effects/ ultrastructureIslets of Langerhans/drug effects/metabolism/ ultrastructureRats
Identifiers
PMID: 6773144
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Other version: http://www.jstor.org/stable/pdfplus/1684233.pdf
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MEDA, Paolo et al. Gap junction development is correlated with insulin content in the pancreatic B cell. In: Science, 1980, vol. 209, n° 4460, p. 1026-1028. https://archive-ouverte.unige.ch/unige:8889

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Deposited on : 2010-07-12

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