fr
Article scientifique
Anglais

Gap junction development is correlated with insulin content in the pancreatic B cell

Publié dansScience, vol. 209, no. 4460, p. 1026-1028
Date de publication1980
Résumé

The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significance correlation was found between these two events.

Mots-clés
  • Animals
  • Cell Communication/drug effects
  • Female
  • Freeze Fracturing
  • Glyburide/ pharmacology
  • Insulin/ metabolism
  • Intercellular Junctions/drug effects/ ultrastructure
  • Islets of Langerhans/drug effects/metabolism/ ultrastructure
  • Rats
Citation (format ISO)
MEDA, Paolo et al. Gap junction development is correlated with insulin content in the pancreatic B cell. In: Science, 1980, vol. 209, n° 4460, p. 1026–1028.
Fichiers principaux (1)
Article
accessLevelRestricted
Identifiants
ISSN du journal0036-8075
455vues
0téléchargements

Informations techniques

Création12/07/2010 11:58:56
Première validation12/07/2010 11:58:56
Heure de mise à jour14/03/2023 15:51:56
Changement de statut14/03/2023 15:51:56
Dernière indexation12/02/2024 18:54:12
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack