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Title

Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien
Authors
Trombella, Sara
Assal, Frédéric
Zekry Berger, Dina Selma
Gold, Gabriel
Giannakopoulos, Panteleimon
Garibotto, Valentina
Démonet, Jean-François
Frisoni, Giovanni
Published in Revue médicale suisse. 2016, vol. 12, no. 515, p. 795-798
Abstract To improve the clinical detection of Alzheimer's disease (AD) new diagnostic criteria have been proposed, based on biomarkers of synaptic dysfunction, AD-related neurodegeneration, and Aβ cerebral amyloidosis. Magnetic resonance imaging (MRI) and position emission tomography (PET) neuroimaging can be configured as powerful means for the detection of medial-temporal atrophy, reduced uptake of 18F-FDG PET or and increased retention of Aβ amyloid protein by amyloïd-PET. In this review, we will discuss these promising techniques that allow assessing in vivo AD pathology and help clinicians to better diagnose and follow-up patients, particularly in clinical trials using disease-modifying treatments.
Keywords Alzheimer Disease/cerebrospinal fluid/diagnosis/pathology — Amyloid beta-Peptides/cerebrospinal fluid — Biomarkers/cerebrospinal fluid — Brain/pathology — Fluorodeoxyglucose F18/administration & dosage — Humans — Image Interpretation, Computer-Assisted — Magnetic Resonance Imaging/methods — Neuroimaging/methods — Positron-Emission Tomography/methods — Predictive Value of Tests — Radiopharmaceuticals/administration & dosage — Sensitivity and Specificity — tau Proteins/cerebrospinal fluid
Identifiers
PMID: 27276723
Full text
Article (Published version) (3.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale
Faculté de médecine / Section de médecine clinique / Département de médecine interne générale, de réhabilitation et de gériatrie
Research groups Neuropsychologie et neurologie comportementale (951)
Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
Troubles de mémoire et maladie d'Alzeimer (935)
Citation
(ISO format) 		TROMBELLA, Sara et al. Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien. In: Revue médicale suisse, 2016, vol. 12, n° 515, p. 795-798. https://archive-ouverte.unige.ch/unige:88672

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Deposited on : 2016-11-03

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