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Imagerie cérébrale de la maladie d'Alzheimer : état de l'art et perspectives pour le clinicien |
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Published in | Revue médicale suisse. 2016, vol. 12, no. 515, p. 795-798 | |
Abstract | To improve the clinical detection of Alzheimer's disease (AD) new diagnostic criteria have been proposed, based on biomarkers of synaptic dysfunction, AD-related neurodegeneration, and Aβ cerebral amyloidosis. Magnetic resonance imaging (MRI) and position emission tomography (PET) neuroimaging can be configured as powerful means for the detection of medial-temporal atrophy, reduced uptake of 18F-FDG PET or and increased retention of Aβ amyloid protein by amyloïd-PET. In this review, we will discuss these promising techniques that allow assessing in vivo AD pathology and help clinicians to better diagnose and follow-up patients, particularly in clinical trials using disease-modifying treatments. | |
Keywords | Alzheimer Disease/cerebrospinal fluid/diagnosis/pathology — Amyloid beta-Peptides/cerebrospinal fluid — Biomarkers/cerebrospinal fluid — Brain/pathology — Fluorodeoxyglucose F18/administration & dosage — Humans — Image Interpretation, Computer-Assisted — Magnetic Resonance Imaging/methods — Neuroimaging/methods — Positron-Emission Tomography/methods — Predictive Value of Tests — Radiopharmaceuticals/administration & dosage — Sensitivity and Specificity — tau Proteins/cerebrospinal fluid | |
Identifiers | PMID: 27276723 | |
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Research groups | Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577) Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984) Neuropsychologie et neurologie comportementale (951) Troubles de mémoire et maladie d'Alzeimer (935) | |
Citation (ISO format) | TROMBELLA, Sara et al. Imagerie cérébrale de la maladie d'Alzheimer : état de l'art et perspectives pour le clinicien. In: Revue médicale suisse, 2016, vol. 12, n° 515, p. 795-798. https://archive-ouverte.unige.ch/unige:88672 |