Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien

Trombella, Sara; Assal, Frédéric; Zekry Berger, Dina Selma; Gold, Gabriel; Giannakopoulos, Panteleimon; Garibotto, Valentina; Démonet, Jean-François; Frisoni, Giovanni

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Title		Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien
Authors		Trombella, Sara Assal, Frédéric Zekry Berger, Dina Selma Gold, Gabriel Giannakopoulos, Panteleimon Garibotto, Valentina Démonet, Jean-François Frisoni, Giovanni
Published in		Revue médicale suisse. 2016, vol. 12, no. 515, p. 795-798
Abstract		To improve the clinical detection of Alzheimer's disease (AD) new diagnostic criteria have been proposed, based on biomarkers of synaptic dysfunction, AD-related neurodegeneration, and Aβ cerebral amyloidosis. Magnetic resonance imaging (MRI) and position emission tomography (PET) neuroimaging can be configured as powerful means for the detection of medial-temporal atrophy, reduced uptake of 18F-FDG PET or and increased retention of Aβ amyloid protein by amyloïd-PET. In this review, we will discuss these promising techniques that allow assessing in vivo AD pathology and help clinicians to better diagnose and follow-up patients, particularly in clinical trials using disease-modifying treatments.
Keywords		Alzheimer Disease/cerebrospinal fluid/diagnosis/pathology — Amyloid beta-Peptides/cerebrospinal fluid — Biomarkers/cerebrospinal fluid — Brain/pathology — Fluorodeoxyglucose F18/administration & dosage — Humans — Image Interpretation, Computer-Assisted — Magnetic Resonance Imaging/methods — Neuroimaging/methods — Positron-Emission Tomography/methods — Predictive Value of Tests — Radiopharmaceuticals/administration & dosage — Sensitivity and Specificity — tau Proteins/cerebrospinal fluid
Identifiers		PMID: 27276723
Full text		Article (Published version) (3.1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de radiologie et informatique médicale Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie
Research groups		Neuropsychologie et neurologie comportementale (951) Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984) Troubles de mémoire et maladie d'Alzeimer (935) Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Citation (ISO format)		TROMBELLA, Sara et al. Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien. In: Revue médicale suisse, 2016, vol. 12, n° 515, p. 795-798. https://archive-ouverte.unige.ch/unige:88672