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Title

Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien

Authors
Démonet, Jean-François
Published in Revue médicale suisse. 2016, vol. 12, no. 515, p. 795-798
Abstract To improve the clinical detection of Alzheimer's disease (AD) new diagnostic criteria have been proposed, based on biomarkers of synaptic dysfunction, AD-related neurodegeneration, and Aβ cerebral amyloidosis. Magnetic resonance imaging (MRI) and position emission tomography (PET) neuroimaging can be configured as powerful means for the detection of medial-temporal atrophy, reduced uptake of 18F-FDG PET or and increased retention of Aβ amyloid protein by amyloïd-PET. In this review, we will discuss these promising techniques that allow assessing in vivo AD pathology and help clinicians to better diagnose and follow-up patients, particularly in clinical trials using disease-modifying treatments.
Keywords Alzheimer Disease/cerebrospinal fluid/diagnosis/pathologyAmyloid beta-Peptides/cerebrospinal fluidBiomarkers/cerebrospinal fluidBrain/pathologyFluorodeoxyglucose F18/administration & dosageHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging/methodsNeuroimaging/methodsPositron-Emission Tomography/methodsPredictive Value of TestsRadiopharmaceuticals/administration & dosageSensitivity and Specificitytau Proteins/cerebrospinal fluid
Identifiers
PMID: 27276723
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Article (Published version) (3.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Neuropsychologie et neurologie comportementale (951)
Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
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(ISO format)
TROMBELLA, Sara et al. Imagerie cérébrale de la maladie d’Alzheimer : état de l’art et perspectives pour le clinicien. In: Revue médicale suisse, 2016, vol. 12, n° 515, p. 795-798. https://archive-ouverte.unige.ch/unige:88672

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Deposited on : 2016-11-03

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