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Imagerie cérébrale de la maladie d'Alzheimer : état de l'art et perspectives pour le clinicien

Démonet, Jean-François
Published in Revue médicale suisse. 2016, vol. 12, no. 515, p. 795-798
Abstract To improve the clinical detection of Alzheimer's disease (AD) new diagnostic criteria have been proposed, based on biomarkers of synaptic dysfunction, AD-related neurodegeneration, and Aβ cerebral amyloidosis. Magnetic resonance imaging (MRI) and position emission tomography (PET) neuroimaging can be configured as powerful means for the detection of medial-temporal atrophy, reduced uptake of 18F-FDG PET or and increased retention of Aβ amyloid protein by amyloïd-PET. In this review, we will discuss these promising techniques that allow assessing in vivo AD pathology and help clinicians to better diagnose and follow-up patients, particularly in clinical trials using disease-modifying treatments.
Keywords Alzheimer Disease/cerebrospinal fluid/diagnosis/pathologyAmyloid beta-Peptides/cerebrospinal fluidBiomarkers/cerebrospinal fluidBrain/pathologyFluorodeoxyglucose F18/administration & dosageHumansImage Interpretation, Computer-AssistedMagnetic Resonance Imaging/methodsNeuroimaging/methodsPositron-Emission Tomography/methodsPredictive Value of TestsRadiopharmaceuticals/administration & dosageSensitivity and Specificitytau Proteins/cerebrospinal fluid
PMID: 27276723
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Research groups Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Laboratoire de neuroimagerie et de traceurs moléculaires innovants (984)
Neuropsychologie et neurologie comportementale (951)
Troubles de mémoire et maladie d'Alzeimer (935)
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TROMBELLA, Sara et al. Imagerie cérébrale de la maladie d'Alzheimer : état de l'art et perspectives pour le clinicien. In: Revue médicale suisse, 2016, vol. 12, n° 515, p. 795-798. https://archive-ouverte.unige.ch/unige:88672

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Deposited on : 2016-11-03

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