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Title

In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology

Authors
Herwerth, Marina
Kalluri, Sudhakar Reddy
Srivastava, Rajneesh
Kleele, Tatjana
Kenet, Selin
Illes, Zsolt
Bennett, Jeffrey L
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Published in Annals of Neurology. 2016
Abstract Neuromyelitis optica (NMO) is an autoimmune disease of the CNS, which resembles multiple sclerosis (MS). NMO differs from MS, however, in the distribution and histology of neuroinflammatory lesions and shows a more aggressive clinical course. Moreover, the majority of NMO patients carry IgG autoantibodies against aquaporin-4 (AQP4), an astrocytic water channel. Antibodies against AQP4 can damage astrocytes via complement, but NMO histopathology also shows demyelination, and - importantly - axon injury, which may determine permanent deficits following NMO relapses. The dynamics of astrocyte injury in NMO and the mechanisms by which toxicity spreads to axons are not understood.
Identifiers
PMID: 26946517
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Structures
Research group La Sclérose en plaques (908)
Project FNS: PP00P3_152928
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HERWERTH, Marina et al. In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. In: Annals of Neurology, 2016. https://archive-ouverte.unige.ch/unige:88584

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Deposited on : 2016-11-02

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