Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

Prasad, Rashmi B; Lessmark, Anna; Almgren, Peter; Kovacs, Györgyi; Hansson, Ola; Oskolkov, Nikolay; Vitai, Marta; Ladenvall, Claes; Kovacs, Peter; Fadista, Joao; Lachmann, Michael; Zhou, Yuedan; Sonestedt, Emily; Poon, Wenny; Wollheim, Claes; Orho-Melander, Marju; Stumvoll, Michael; Tuomi, Tiinamaija; Pääbo, Svante; Koranyi, Laszlo; Groop, Leif

doi:10.1007/s00125-016-3973-9

Scientific article

English

Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

Published inDiabetologia, vol. 59, no. 8, p. 1702-1713

Publication date2016

Abstract

Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families.

Keywords

Families
Genetic association studies
KCNQ1
Maternal effects
Methylation
Parent-of-origin
Parental transmission
THADA
Type 2 diabetes

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de physiologie cellulaire et métabolisme

Citation (ISO format)

PRASAD, Rashmi B et al. Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes. In: Diabetologia, 2016, vol. 59, n° 8, p. 1702–1713. doi: 10.1007/s00125-016-3973-9

Article (Published version)

Identifiers

PID : unige:88476
DOI : 10.1007/s00125-016-3973-9
PMID : 27155871

Journal ISSN0012-186X

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Creation30/08/2016 16:48:00

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Update15/03/2023 00:51:55

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Excess maternal transmission of variants in the THADA gene to offspring with type 2 diabetes

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