Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes
Contributeurs/tricesHiguchi, Y.; Herrera, Pedro Luis; Muniesa, P.; Huarte, Joachim; Belin, Dominique; Ohashi, P.; Aichele, P.; Orci, Lelio; Vassalli, Jean-Dominique; Vassalli, Pierre
Publié dansThe Journal of experimental medicine, vol. 176, no. 6, p. 1719-1731
Date de publication1992
Résumé
Mots-clés
- Animals
- Base Sequence
- Cyclophosphamide
- Diabetes Mellitus, Experimental/chemically induced/physiopathology
- Diabetes Mellitus, Type 1/genetics
- Insulin/genetics
- Interferon-gamma
- Interleukin-1
- Interleukin-2
- Islets of Langerhans/ metabolism/pathology
- Mice
- Mice, Inbred C57BL
- Mice, Inbred NOD
- Mice, Inbred Strains
- Mice, Transgenic
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Pancreatic Diseases/ genetics/metabolism/pathology
- Polymerase Chain Reaction
- Promoter Regions, Genetic
- Rats
- Sulfates/metabolism
- Sulfur Radioisotopes
- Tumor Necrosis Factor-alpha/biosynthesis/ genetics
Structure d'affiliation
Citation (format ISO)
HIGUCHI, Y. et al. Expression of a tumor necrosis factor alpha transgene in murine pancreatic beta cells results in severe and permanent insulitis without evolution towards diabetes. In: The Journal of experimental medicine, 1992, vol. 176, n° 6, p. 1719–1731. doi: 10.1084/jem.176.6.1719
Fichiers principaux (1)
Article
Identifiants
- PID : unige:8812
- DOI : 10.1084/jem.176.6.1719
- PMID : 1460428
ISSN du journal0022-1007