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Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

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Published in Development. 2000, vol. 127, no. 11, p. 2317-2322
Abstract To analyze cell lineage in the pancreatic islets, we have irreversibly tagged all the progeny of cells through the activity of Cre recombinase. Adult glucagon alpha and insulin beta cells are shown to derive from cells that have never transcribed insulin or glucagon, respectively. Also, the beta-cell progenitors, but not alpha-cell progenitors, transcribe the pancreatic polypeptide (PP) gene. Finally, the homeodomain gene PDX1, which is expressed by adult beta-cells, is also expressed by alpha-cell progenitors. Thus the islet alpha- and beta-cell lineages appear to arise independently during ontogeny, probably from a common precursor.
Keywords AnimalsCell DifferentiationCell LineageFemaleGene ExpressionGlucagon/ biosynthesis/geneticsHomeodomain Proteins/geneticsHumansInsulin/ biosynthesis/geneticsIslets of Langerhans/ cytology/metabolismMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, TransgenicPancreatic Polypeptide/geneticsStem Cells/cytology/metabolismTrans-Activators/genetics
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PMID: 10804174
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Other version: http://dev.biologists.org/content/127/11/2317.full.pdf
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HERRERA, Pedro Luis. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. In: Development, 2000, vol. 127, n° 11, p. 2317-2322. https://archive-ouverte.unige.ch/unige:8804

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Deposited on : 2010-07-12

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