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Stabilization of beta-catenin impacts pancreas growth

Heiser, P. W.
Lau, Janet
Taketo, M. M.
Hebrok, Matthias
Published in Development. 2006, vol. 133, no. 10, p. 2023-2032
Abstract A recent study has shown that deletion of beta-catenin within the pancreatic epithelium results in a loss of pancreas mass. Here, we show that ectopic stabilization of beta-catenin within mouse pancreatic epithelium can have divergent effects on both organ formation and growth. Robust stabilization of beta-catenin during early organogenesis drives changes in hedgehog and Fgf10 signaling and induces a loss of Pdx1 expression in early pancreatic progenitor cells. Together, these perturbations in early pancreatic specification culminate in a severe reduction of pancreas mass and postnatal lethality. By contrast, inducing the stabilized form of beta-catenin at a later time point in pancreas development causes enhanced proliferation that results in a dramatic increase in pancreas organ size. Taken together, these data suggest a previously unappreciated temporal/spatial role for beta-catenin signaling in the regulation of pancreas organ growth.
Keywords AnimalsCell ProliferationEpithelial Cells/cytology/physiologyFibroblast Growth Factor 10/physiologyHedgehog ProteinsHomeodomain Proteins/physiologyMiceOrgan SizeOrganogenesisPancreas/cytology/ embryology/ growth & developmentSignal TransductionStem Cells/metabolismTime FactorsTrans-Activators/metabolism/physiologyBeta Catenin/ physiology
PMID: 16611688
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Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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HEISER, P. W. et al. Stabilization of beta-catenin impacts pancreas growth. In: Development, 2006, vol. 133, n° 10, p. 2023-2032. doi: 10.1242/dev.02366 https://archive-ouverte.unige.ch/unige:8801

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Deposited on : 2010-07-12

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