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Title

Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections

Authors
Vincent, Jean-Louis
Brealey, David
Libert, Nicolas
O'Dwyer, Michael
Zacharowski, Kai
Mikaszewska-Sokolewicz, Malgorzata
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Published in Critical Care Medicine. 2015, vol. 43, no. 11, p. 2283-2291
Abstract Early identification of causative microorganism(s) in patients with severe infection is crucial to optimize antimicrobial use and patient survival. However, current culture-based pathogen identification is slow and unreliable such that broad-spectrum antibiotics are often used to insure coverage of all potential organisms, carrying risks of overtreatment, toxicity, and selection of multidrug-resistant bacteria. We compared the results obtained using a novel, culture-independent polymerase chain reaction/electrospray ionization-mass spectrometry technology with those obtained by standard microbiological testing and evaluated the potential clinical implications of this technique.
Keywords AdultAgedBacteremia/diagnosis/microbiologyBlood-Borne Pathogens/isolation & purificationBody Fluids/microbiologyCritical Care/methodsCritical IllnessEarly DiagnosisEuropeFemaleGram-Negative Bacteria/isolation & purificationGram-Positive Bacteria/isolation & purificationHumansIntensive Care UnitsMaleMiddle AgedMolecular Diagnostic TechniquesPneumonia, Bacterial/diagnosis/microbiologyPolymerase Chain Reaction/methodsRisk AssessmentSensitivity and SpecificitySpecimen HandlingSpectrometry, Mass, Electrospray Ionization/methods
Identifiers
PMID: 26327198
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Research group Analyse génomique et fonctionnelle du staphylocoque doré (604)
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VINCENT, Jean-Louis et al. Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections. In: Critical Care Medicine, 2015, vol. 43, n° 11, p. 2283-2291. https://archive-ouverte.unige.ch/unige:87996

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Deposited on : 2016-10-05

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