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Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

Hashimoto, Naoko
Kido, Yoshiaki
Uchida, Tohru
Asahara, Shun-ichiro
Shigeyama, Yutaka
Matsuda, Tomokazu
Takeda, Akihiko
Tsuchihashi, Daisuke
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Published in Nature genetics. 2006, vol. 38, no. 5, p. 589-593
Abstract The total mass of islets of Langerhans is reduced in individuals with type 2 diabetes, possibly contributing to the pathogenesis of this condition. Although the regulation of islet mass is complex, recent studies have suggested the importance of a signaling pathway that includes the insulin or insulin-like growth factor-1 receptors, insulin receptor substrate and phosphatidylinositol (PI) 3-kinase. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that mediates signaling downstream of PI 3-kinase. Here we show that mice that lack PDK1 specifically in pancreatic beta cells (betaPdk1-/- mice) develop progressive hyperglycemia as a result of a loss of islet mass. The mice show reductions in islet density as well as in the number and size of cells. Haploinsufficiency of the gene for the transcription factor Foxo1 resulted in a marked increase in the number, but not the size, of cells and resulted in the restoration of glucose homeostasis in betaPdk1-/- mice. These results suggest that PDK1 is important in maintenance of pancreatic cell mass and glucose homeostasis.
Keywords AnimalsDiabetes Mellitus, Experimental/enzymology/ genetics/pathologyIslets of Langerhans/ enzymology/ pathologyMiceMice, KnockoutProtein-Serine-Threonine Kinases/ geneticsSignal Transduction
PMID: 16642023
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Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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HASHIMOTO, Naoko et al. Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass. In: Nature genetics, 2006, vol. 38, n° 5, p. 589-593. doi: 10.1038/ng1774 https://archive-ouverte.unige.ch/unige:8795

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Deposited on : 2010-07-12

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