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Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine

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Published in Nature Cell Biology. 2004, vol. 6, no. 11, p. 1021-1025
Abstract Replacing missing insulin-producing beta cells to treat diabetes is a major challenge for regenerative medicine. A better understanding of beta-cell embryogenesis and regeneration in adult life is needed to devise means to derive these specialized cells in sufficiently large numbers from stem or precursor cells. It is also critical to ensure that any surrogate or regenerated beta cells have perfectly regulated insulin production, which is essential for physiological glucose homeostasis.
Keywords AdultDiabetes Mellitus/therapyHumansInsulin/biosynthesis/secretionIslets of Langerhans/ pathology/secretionRegeneration
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PMID: 15516994
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HALBAN, Philippe A. Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine. In: Nature Cell Biology, 2004, vol. 6, n° 11, p. 1021-1025. https://archive-ouverte.unige.ch/unige:8780

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Deposited on : 2010-07-12

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