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Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications

Donath, M. Y.
Published in Diabetologia. 2004, vol. 47, no. 3, p. 581-589
Abstract Increasing evidence indicates that decreased functional beta-cell mass is the hallmark of both Type 1 and Type 2 diabetes. This underlies the absolute or relative insulin insufficiency in both conditions. In this For Debate, we consider the possible mechanisms responsible for beta-cell death and impaired function and their relative contribution to insulin insufficiency in diabetes. Beta-cell apoptosis and impaired proliferation consequent to hyperglycaemia is one pathway that could be operating in all forms of diabetes. Autoimmunity and other routes to beta-cell death are also considered. Recognition of decreased functional beta-cell mass and its overlapping multifactorial aetiology in diabetic states, leads us to propose a unifying classification of diabetes.
Keywords Cell DeathDiabetes Mellitus/ pathologyDiabetes Mellitus, Type 2/pathology/ physiopathologyHumansInsulin/secretionIslets of Langerhans/ anatomy & histology/pathology
PMID: 14767595
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DONATH, M. Y., HALBAN, Philippe A. Decreased beta-cell mass in diabetes: significance, mechanisms and therapeutic implications. In: Diabetologia, 2004, vol. 47, n° 3, p. 581-589. https://archive-ouverte.unige.ch/unige:8728

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Deposited on : 2010-07-12

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