UNIGE document Scientific Article
previous document  unige:8727  next document
add to browser collection
Title

Cytokine production by islets in health and diabetes: cellular origin, regulation and function

Authors
Donath, M. Y.
Boni-Schnetzler, Marianne
Ellingsgaard, Helga
Ehses, J. A.
Published in Trends in Endocrinology and Metabolism. 2010, vol. 21, no. 5, p. 261-267
Abstract Islets produce a variety of cytokines and chemokines in response to physiologic and pathologic stimulation by nutrients. The cellular source of these inflammatory mediators includes alpha-, beta-, endothelial-, ductal- and recruited immune cells. Islet-derived cytokines promote alpha- and beta-cell adaptation and repair in the short term. Eventually, chronic metabolic stress can induce a deleterious autoinflammatory process in islets leading to insulin secretion failure and type 2 diabetes. Understanding the specific role of islet derived cytokines and chemokines has opened the door to targeted clinical interventions aimed at remodeling islet inflammation from destruction to adaptation. In this article, we review the islet cellular origin of various cytokines and chemokines and describe their regulation and respective roles in physiology and diabetes.
Identifiers
PMID: 20096598
Full text
Structures
Citation
(ISO format)
DONATH, M. Y. et al. Cytokine production by islets in health and diabetes: cellular origin, regulation and function. In: Trends in Endocrinology and Metabolism, 2010, vol. 21, n° 5, p. 261-267. https://archive-ouverte.unige.ch/unige:8727

173 hits

1 download

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :