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Conserved non-genic sequences - an unexpected feature of mammalian genomes

Published in Nature reviews. Genetics. 2005, vol. 6, no. 2, p. 151-157
Abstract Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?
Keywords AnimalsBase Sequence/geneticsComputational BiologyConserved Sequence/ geneticsDNA, Intergenic/ geneticsEvolution, MolecularGenetic VariationGenomeHumansModels, GeneticPhenotype
PMID: 15716910
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Other version: http://www.nature.com/nrg/journal/v6/n2/pdf/nrg1527.pdf
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DERMITZAKIS, Emmanouil, REYMOND, Alexandre, ANTONARAKIS, Stylianos. Conserved non-genic sequences - an unexpected feature of mammalian genomes. In: Nature reviews. Genetics, 2005, vol. 6, n° 2, p. 151-157. doi: 10.1038/nrg1527 https://archive-ouverte.unige.ch/unige:8718

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Deposited on : 2010-07-12

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