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Scientific article
English

Conserved non-genic sequences - an unexpected feature of mammalian genomes

Published inNature reviews. Genetics, vol. 6, no. 2, p. 151-157
Publication date2005
Abstract

Mammalian genomes contain highly conserved sequences that are not functionally transcribed. These sequences are single copy and comprise approximately 1-2% of the human genome. Evolutionary analysis strongly supports their functional conservation, although their potentially diverse, functional attributes remain unknown. It is likely that genomic variation in conserved non-genic sequences is associated with phenotypic variability and human disorders. So how might their function and contribution to human disorders be examined?

Keywords
  • Animals
  • Base Sequence/genetics
  • Computational Biology
  • Conserved Sequence/ genetics
  • DNA, Intergenic/ genetics
  • Evolution, Molecular
  • Genetic Variation
  • Genome
  • Humans
  • Models, Genetic
  • Phenotype
Citation (ISO format)
DERMITZAKIS, Emmanouil, REYMOND, Alexandre, ANTONARAKIS, Stylianos. Conserved non-genic sequences - an unexpected feature of mammalian genomes. In: Nature reviews. Genetics, 2005, vol. 6, n° 2, p. 151–157. doi: 10.1038/nrg1527
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ISSN of the journal1471-0056
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