Scientific article
Open access

The emerging role of insulin-like growth factors in testis development and function

Published inBasic and clinical andrology, vol. 24, 12
Publication date2014

The insulin-like family of growth factors (IGFs) - composed of insulin, and insulin-like growth factors I (IGF1) and II (IGF2) - provides essential signals for the control of testis development and function. In the testis, IGFs act in an autocrine-paracrine manner but the extent of their actions has been underestimated due to redundancies at both the ligand and receptor levels, and the perinatal lethality of constitutive knockout mice. This review synthesizes the current understanding of how the IGF system regulates biological processes such as primary sex determination, testis development, spermatogenesis and steroidogenesis, and highlights the questions that remain to be explored.

Citation (ISO format)
GRIFFETH, Richard J, BIANDA, Vanessa, NEF, Serge. The emerging role of insulin-like growth factors in testis development and function. In: Basic and clinical andrology, 2014, vol. 24, p. 12. doi: 10.1186/2051-4190-24-12
Main files (1)
Article (Published version)
ISSN of the journal2051-4190

Technical informations

Creation08/26/2016 2:47:00 PM
First validation08/26/2016 2:47:00 PM
Update time03/15/2023 12:41:59 AM
Status update03/15/2023 12:41:58 AM
Last indexation05/02/2024 5:43:55 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack