Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion
ContributorsBouzakri, Karim; Ribaux, Pascale; Halban, Philippe A.
Published inThe Journal of biological chemistry, vol. 284, no. 41, p. 27892-27898
Publication date2009
Abstract
Keywords
- Animals
- Cell Death/drug effects
- Cell Proliferation/drug effects
- Cells, Cultured
- Diabetes Mellitus, Type 2/metabolism
- Glucose/ metabolism
- Humans
- Insulin/ secretion
- Insulin Receptor Substrate Proteins/genetics/ metabolism
- Insulin-Secreting Cells/cytology/ drug effects/ metabolism
- Intracellular Signaling Peptides and Proteins/genetics/ metabolism
- Male
- Mitogen-Activated Protein Kinases/metabolism
- NF-kappa B/metabolism
- Nitric Oxide Synthase/metabolism
- Protein-Serine-Threonine Kinases/genetics/ metabolism
- Proto-Oncogene Proteins c-akt/metabolism
- Rats
- Rats, Wistar
- Signal Transduction/drug effects
- Tumor Necrosis Factor-alpha/ pharmacology
- Tyrosine/metabolism
Affiliation
Citation (ISO format)
BOUZAKRI, Karim, RIBAUX, Pascale, HALBAN, Philippe A. Silencing mitogen-activated protein 4 kinase 4 (MAP4K4) protects beta cells from tumor necrosis factor-alpha-induced decrease of IRS-2 and inhibition of glucose-stimulated insulin secretion. In: The Journal of biological chemistry, 2009, vol. 284, n° 41, p. 27892–27898. doi: 10.1074/jbc.M109.048058
Main files (1)
Article
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Identifiers
- PID : unige:8655
- DOI : 10.1074/jbc.M109.048058
- PMID : 19690174
Commercial URLhttp://www.jbc.org/content/284/41/27892.full.pdf
ISSN of the journal0021-9258