This article analyses if and how recent changes within the Swiss political system have influenced different aspects of protest politics (e.g. level, issues, action repertoires, and transnationalization). We argue that opportunities for mobilization have emerged in recent years due to changes in the institutionalized political context and that these changes have at least partially led to a resurgence of protest activities in the early 2000s. In a longitudinal perspective, it is however rather moderate. Additionally, new social movements still dominate Swiss protest politics. Although social and migration- related questions gained in salience, the changes are not as dramatic as in the case of party politics. The rise of a new integration-demarcation cleavage has not (yet) shaken Swiss protest politics as heavily as Swiss party politics. Finally, even though they are not integrated into a pronounced new protest cycle, the early 2000s are marked by the global justice movement. In this context, we observe a slight radicalization of the action repertoire and police reactions, which is at least partially explained by the emergence of new “transnational” sites of contention.