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Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection

Muschaweckh, Andreas
Drexler, Ingo
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Published in The Journal of experimental medicine. 2016, vol. 213, no. 8, p. 1571-1587
Abstract Tissue-resident memory T cells (TRM) persist at sites of prior infection and have been shown to enhance pathogen clearance by recruiting circulating immune cells and providing bystander activation. Here, we characterize the functioning of brain-resident memory T cells (bTRM) in an animal model of viral infection. bTRM were subject to spontaneous homeostatic proliferation and were largely refractory to systemic immune cell depletion. After viral reinfection in mice, bTRM rapidly acquired cytotoxic effector function and prevented fatal brain infection, even in the absence of circulating CD8(+) memory T cells. Presentation of cognate antigen on MHC-I was essential for bTRM-mediated protective immunity, which involved perforin- and IFN-γ-dependent effector mechanisms. These findings identify bTRM as an organ-autonomous defense system serving as a paradigm for TRM functioning as a self-sufficient first line of adaptive immunity.
PMID: 27377586
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Article (Published version) (4.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group La Sclérose en plaques (908)
Swiss National Science Foundation: PP00P3_152928
Autre: Tschira Foundation, Gebert Rüf Foundation
(ISO format)
STEINBACH, Karin et al. Brain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection. In: The Journal of experimental medicine, 2016, vol. 213, n° 8, p. 1571-1587. doi: 10.1084/jem.20151916 https://archive-ouverte.unige.ch/unige:86049

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Deposited on : 2016-08-16

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