Solar ultraviolet (UV) radiation has a dual effect on human health. Low UV doses promote calcium and phosphorous metabolic regulation and vitamin D photosynthesis, while an excessive UV exposure is the main cause of skin cancer, along with eye diseases and premature skin ageing. Nevertheless, the dose-response between ultraviolet exposure patterns and skin cancer occurrence is not fully understood since exposure data are limited and individual anatomical variations in UV doses are large. For these reasons, a numeric simulation tool (SimUVEx) has been developed and validated in order to predict the dose and distribution of UV exposure received on the basis of ground irradiation and morphological data. SimUVEx is based on 3D graphics techniques usually used to render virtual environments to estimate the solar exposure of a virtual manikin depicted as a triangle mesh surface. The amount of solar energy received by each triangle is calculated taking into account direct, reflected and diffuse radiation, body surface orientation to the sun and shading from other body parts. The goals of the second version of SimUVEx are to move from individual-based to population-based (e.g., Switzerland and, eventually, Europe) exposure assessment, expanding temporal, spatial and morphological simulation capabilities. Outputs from SimUVEx version 2 will allow building exposure scenarios, identifying high-risk situations and producing reference dose ranges for common outdoor occupational and leisure activities.