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Poly(ortho esters) - their development and some recent applications

Heller, Jorge
Barr, J.
Ng, S.Y.
Shen, H.R.
Published in European journal of pharmaceutics and biopharmaceutics. 2000, vol. 50, no. 1, p. 121-128
Abstract Poly(ortho esters) have been under development since the early 1970s and four families of such polymers have been described. Of most interest are poly(ortho ester) III and poly(ortho ester) IV. Poly(ortho ester) III is a semisolid material that has been shown to be highly biocompatible and is currently being investigated as an adjunct to glaucoma filtering surgery and other ocular applications. However, the polymerization is difficult to control and is not readily scaled up. Poly(ortho ester) IV can be easily prepared in a highly reproducible manner, is very stable provided moisture is rigorously excluded and has also been shown to be highly biocompatible. It is currently under development for a variety of applications, such as ocular delivery, protein release, post-operative pain treatment and post-operative cancer treatment.
Keywords Poly(ortho esters)DevelopmentsApplicationsPolymerization
PMID: 10840196
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HELLER, Jorge et al. Poly(ortho esters) - their development and some recent applications. In: European journal of pharmaceutics and biopharmaceutics, 2000, vol. 50, n° 1, p. 121-128. doi: 10.1016/s0939-6411(00)00085-0 https://archive-ouverte.unige.ch/unige:85325

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Deposited on : 2016-07-19

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