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Title

An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase

Authors
Gunby, Rosalind Helen
Tartari, Carmen Julia
Porchia, Francesca
Donella-Deana, Arianna
Gambacorti-Passerini, Carlo
Published in Haematologica. 2005, vol. 90, no. 7, p. 988-990
Abstract The discovery of novel anti-cancer drugs targeting anaplastic lymphoma kinase (ALK), an oncogenic tyrosine kinase, raises the need for in vitro assays suitable for screening compounds for ALK inhibition. To this aim we have developed and optimized an ALK-specific enzyme-linked immunosorbent assay that employs a novel ALK peptide substrate and purified ALK kinase domain.
Keywords Amino Acid SequenceAnimalsDose-Response RelationshipDrugDrug Screening AssaysAntitumor/methodsEnzyme Inhibitors/pharmacologyEnzyme-Linked Immunosorbent Assay/methodsHumansMiceMolecular Sequence DataPeptides/chemistryPhosphorylationProtein StructureTertiaryProtein-Tyrosine Kinases/antagonists & inhibitorsReceptor Protein-Tyrosine KinasesStaurosporine/pharmacology
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PMID: 15996942
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GUNBY, Rosalind Helen et al. An enzyme-linked immunosorbent assay to screen for inhibitors of the oncogenic anaplastic lymphoma kinase. In: Haematologica, 2005, vol. 90, n° 7, p. 988-990. https://archive-ouverte.unige.ch/unige:85273

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Deposited on : 2016-07-14

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