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A common genomic region regulates HoxD dynamic expression in the forming somites and in the vibrissae follicles

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Defense Maîtrise : Univ. Genève, 2016
Abstract During bilaterian embryonic development, Hox genes achieve critical functions in body patterning. The vertebrate trunk elongates by cyclic addition of blocks of mesoderm called somites. During this process, Hox genes instruct the forming segments with their positional identity. Hox genes have also been co-opted several times with the emergence of secondary structures. They have been described in axial tissues like digits, genitalia or hairs. In 2001, Zakany et al. showed that some Hox genes adopt a dynamic expression in the forming somites. In this study, we demonstrate that anterior Hoxd genes adopt dynamic transcription patterns in the vibrissae follicles, reminiscent to that found in the forming somites. Our results indicate that genomic features established in the somites have probably impacted the implementation of a new regulatory mechanisms acting in the whisker pad. Hence, our report supports the idea that higher order chromatin structure promotes the appearance of new enhancers.
Keywords HoxSomitogenesisVibrissaeHairsRegulationEnhancers
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Research group Groupe Duboule
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HINTERMANN, Aurélie. A common genomic region regulates HoxD dynamic expression in the forming somites and in the vibrissae follicles. Université de Genève. Maîtrise, 2016. https://archive-ouverte.unige.ch/unige:85255

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Deposited on : 2016-07-13

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