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Characterization and classification of matrix effects in biological samples analyses

Marchi, Ivano
Saugy, Martial
Published in Journal of chromatography. 2010, vol. 1217, no. 25, p. 4071-8
Abstract An exhaustive classification of matrix effects occurring when a sample preparation is performed prior to liquid-chromatography coupled to mass spectrometry (LC-MS) analyses was proposed. A total of eight different situations were identified allowing the recognition of the matrix effect typology via the calculation of four recovery values. A set of 198 compounds was used to evaluate matrix effects after solid phase extraction (SPE) from plasma or urine samples prior to LC-ESI-MS analysis. Matrix effect identification was achieved for all compounds and classified through an organization chart. Only 17% of the tested compounds did not present significant matrix effects.
Keywords Matrix effectsIon suppressionPlasmaUrineSample preparationSPEMS
PMID: 19744661
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MARCHI, Ivano et al. Characterization and classification of matrix effects in biological samples analyses. In: Journal of chromatography, 2010, vol. 1217, n° 25, p. 4071-8. doi: 10.1016/j.chroma.2009.08.061 https://archive-ouverte.unige.ch/unige:8502

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Deposited on : 2010-07-01

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