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Title

TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke

Authors
Gallego-Fabrega, Cristina
Carrera, Caty
Slowik, Agnieszka
Pera, Joanna
Pezzini, Alessandro
Serrano-Heras, Gemma
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Published in Stroke. 2016, vol. 47, no. 5, p. 1180-6
Abstract Clopidogrel is one of the most used antiplatelet drugs in patients with cardiovascular disease. However, 16% to 50% of patients have a high on-clopidogrel platelet reactivity and an increased risk of ischemic events. The pathogenesis of high on-treatment platelet reactivity in patients with stroke is only partially explained by genetic variations. This study aims to find differentially methylated sites across the genome associated with vascular recurrence in ischemic stroke patients treated with clopidogrel.
Keywords AspirinClopidogrelMethylationStrokeVascular resistance
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PMID: 27026631
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Article (Published version) (1.4 MB) - document accessible for UNIGE members only Limited access to UNIGE
Other version: http://stroke.ahajournals.org/content/47/5/1180
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Research group Geneva Platelet Group (13)
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GALLEGO-FABREGA, Cristina et al. TRAF3 Epigenetic Regulation Is Associated With Vascular Recurrence in Patients With Ischemic Stroke. In: Stroke, 2016, vol. 47, n° 5, p. 1180-6. https://archive-ouverte.unige.ch/unige:84481

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Deposited on : 2016-06-13

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