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Title

Sensitive and selective determination of methylenedioxylated amphetamines by high-performance liquid chromatography with fluorimetric detection
Authors
Sadeghipour, Farshid
Veuthey, Jean-Luc
Published in Journal of Chromatography. A. 1997, vol. 787, no. 1-2, p. 137-43
Abstract A rapid, sensitive and selective liquid chromatographic method with fluorimetric detection was developed for the separation and quantification of four methylenedioxylated amphetamines without interference of other drugs of abuse and common substances found in illicit tablets. The method was validated by examining linearity, precision and accuracy as well as detection and quantification limits. Methylenedioxylated amphetamines were quantified in eight tablets from illicit drug seizures and results were quantitatively compared to HPLC-UV analyses. To demonstrate the better sensitivity of the fluorimetric detection, methylenedioxylated amphetamines were analyzed in serum after a liquid-liquid extraction procedure and results were also compared to HPLC-UV analyses.
Keywords 3,4-Methylenedioxyamphetamine/analogs & derivatives/blood — Amphetamines/blood — Chromatography, High Pressure Liquid — Humans — N-Methyl-3,4-methylenedioxyamphetamine/blood — Reproducibility of Results — Sensitivity and Specificity — Spectrometry, Fluorescence — Spectrophotometry, Ultraviolet — Substance Abuse Detection/methods — Tablets
Identifiers
PMID: 9409000
Full text
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Structures
Faculté des sciences / Section des sciences pharmaceutiques
Citation
(ISO format) 		SADEGHIPOUR, Farshid, VEUTHEY, Jean-Luc. Sensitive and selective determination of methylenedioxylated amphetamines by high-performance liquid chromatography with fluorimetric detection. In: Journal of Chromatography. A, 1997, vol. 787, n° 1-2, p. 137-43. doi: 10.1016/S0021-9673(97)00817-0 https://archive-ouverte.unige.ch/unige:8444

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Deposited on : 2010-06-24

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