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Title

Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples
Authors
Kohler, Marcel
Haerdi, Werner
Christen, Philippe
Veuthey, Jean-Luc
Published in Phytochemical Analysis. 1997, vol. 8, no. 5, p. 223-227
Abstract Artemisinin and artemisinic acid were extracted from aerial parts of Artemisia annua by supercritical fluid extraction (SFE) with carbon dioxide modified with 3% (v/v) methanol. The quantitative determination of both compounds was carried out by supercritical fluid chromatography (SFC) coupled with an evaporative light scattering detector (SFC-ELSD). Results obtained by SFE-SFC-ELSD show that this method allows mild extraction conditions and quantitative determination without further purification of the plant extract. In all cases, artemisinin and artemisinic acid were extracted in a higher yield with supercritical carbon dioxide than with liquid-solid extraction. © 1997 John Wiley & Sons, Ltd.
Keywords Supercritical fluid extraction — Supercritical fluid chromatography — Evaporative light scattering detector — Artemisinin — Artemisinic acid — Artemisia annua
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Article (Published version) (104 Kb) - document accessible for UNIGE members only Limited access to UNIGE
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Faculté des sciences / Section des sciences pharmaceutiques
Citation
(ISO format) 		KOHLER, Marcel et al. Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples. In: Phytochemical Analysis, 1997, vol. 8, n° 5, p. 223-227. doi: 10.1002/(SICI)1099-1565(199709/10)8:5<223::AID-PCA370>3.0.CO;2-A https://archive-ouverte.unige.ch/unige:8439

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Deposited on : 2010-06-24

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