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Scientific article
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Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples

Published inPhytochemical analysis, vol. 8, no. 5, p. 223-227
Publication date1997
Abstract

Artemisinin and artemisinic acid were extracted from aerial parts of Artemisia annua by supercritical fluid extraction (SFE) with carbon dioxide modified with 3% (v/v) methanol. The quantitative determination of both compounds was carried out by supercritical fluid chromatography (SFC) coupled with an evaporative light scattering detector (SFC-ELSD). Results obtained by SFE-SFC-ELSD show that this method allows mild extraction conditions and quantitative determination without further purification of the plant extract. In all cases, artemisinin and artemisinic acid were extracted in a higher yield with supercritical carbon dioxide than with liquid-solid extraction. © 1997 John Wiley & Sons, Ltd.

Keywords
  • Supercritical fluid extraction
  • Supercritical fluid chromatography
  • Evaporative light scattering detector
  • Artemisinin
  • Artemisinic acid
  • Artemisia annua
Citation (ISO format)
KOHLER, Marcel et al. Supercritical fluid extraction and chromatography of artemisinin and artemisinic acid. An improved method for the analysis of Artemisia annua samples. In: Phytochemical analysis, 1997, vol. 8, n° 5, p. 223–227. doi: 10.1002/(SICI)1099-1565(199709/10)8:5<223::AID-PCA370>3.0.CO;2-A
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ISSN of the journal0958-0344
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