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Title

Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections

Authors
Baeyens, V.
Kaltsatos, V.
Boisramé, B.
Balant, L P.
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Published in Journal of Controlled Release. 1998, vol. 52, no. 1-2, p. 215-20
Abstract In the case of external ophthalmic infections, repeated instillations of antibiotics are required to reach therapeutic level, above the minimal inhibitory concentration (MIC). An additional administration of a corticosteroid is often needed, in order to limit the precorneal damages caused by the infection. However, repeated administration of a corticosteroid can increase intraocular pressure and thus lead to glaucoma. To overcome the disadvantages of separated and repeated instillations of two products and to avoid the side effects of dexamethasone, a soluble insert containing gentamicin sulfate and dexamethasone phosphate was developed. The new system ensures the concomitant release of the two drugs during the first 10 h of treatment, followed by an adequate concentration of gentamicin sulfate, above the MIC of 4.0 microgram ml-1, during 50 h, due to a combination of gentamicin sulfate with cellulose acetate phthalate, which reduces the solubility of gentamicin.
Keywords AnimalsAnti-Bacterial Agents/administration & dosageAnti-Inflammatory Agents/administration & dosageDexamethasone/administration & dosage/pharmacokineticsDrug Delivery SystemsEye Infections/drug therapyGentamicins/administration & dosage/pharmacokineticsMaleRabbits
Identifiers
PMID: 9685951
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BAEYENS, V. et al. Optimized release of dexamethasone and gentamicin from a soluble ocular insert for the treatment of external ophthalmic infections. In: Journal of Controlled Release, 1998, vol. 52, n° 1-2, p. 215-20. https://archive-ouverte.unige.ch/unige:8435

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Deposited on : 2010-06-24

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