Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles

Staedler, Davide; Passemard, Solène; Magouroux, Thibaud; Rogov, Andrii; Maguire, Ciaran Manus; Mohamed, Bashir M.; Schwung, Sebastian; Rytz, Daniel; Jüstel, Thomas; Hwu, Stéphanie; Mugnier, Yannick; Le Dantec, Ronan; Volkov, Yuri; Gerber-Lemaire, Sandrine; Prina-Mello, Adriele; Bonacina, Luigi; Wolf, Jean-Pierre

doi:10.1016/j.nano.2014.12.018

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Title		Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles
Authors		Staedler, Davide Passemard, Solène Magouroux, Thibaud Rogov, Andrii Maguire, Ciaran Manus Mohamed, Bashir M. Schwung, Sebastian Rytz, Daniel Jüstel, Thomas Hwu, Stéphanie Mugnier, Yannick Le Dantec, Ronan Volkov, Yuri Gerber-Lemaire, Sandrine Prina-Mello, Adriele Bonacina, Luigi Wolf, Jean-Pierre show all authors [1 - 17]
Published in		Nanomedicine. 2015, vol. 11, no. 4, p. 815-824
Abstract		Bismuth Ferrite (BFO) nanoparticles (BFO-NP) display interesting optical (nonlinear response) and magnetic properties which make them amenable for bio-oriented diagnostic applications as intra- and extra membrane contrast agents. Due to the relatively recent availability of this material in well dispersed nanometric form, its biocompatibility was not known to date. In this study, we present a thorough assessment of the effects of in vitro exposure of human adenocarcinoma (A549), lung squamous carcinoma (NCI-H520), and acute monocytic leukemia (THP-1) cell lines to uncoated and poly(ethylene glycol)-coated BFO-NP in the form of cytotoxicity, haemolytic response and biocompatibility. Our results support the attractiveness of the functional-BFO towards biomedical applications focused on advanced diagnostic imaging.
Identifiers		DOI: 10.1016/j.nano.2014.12.018
Full text		Article (Published version) (1 MB) - Limited access to UNIGE Other version: http://linkinghub.elsevier.com/retrieve/pii/S1549963415000246
Structures		Faculté des sciences / Section de physique / Groupe de physique appliquée
Research group		Groupe Wolf
Citation (ISO format)		STAEDLER, Davide et al. Cellular uptake and biocompatibility of bismuth ferrite harmonic advanced nanoparticles. In: Nanomedicine, 2015, vol. 11, n° 4, p. 815-824. doi: 10.1016/j.nano.2014.12.018 https://archive-ouverte.unige.ch/unige:84334