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Doctoral thesis
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English

Divergence in Hox gene regulation and the evolution of a snake-like body plan

Contributors

Guerreiro, Isabel

Directors

Duboule, Denis

Defense date

2016-04-11

Abstract

While some aspects of vertebrate embryonic development are highly conserved, others are variable and determine the extraordinary morphological variability observed across species. Hox genes are likely candidates in shaping the body plan of organisms over the course of evolution, owing to their instrumental functions in the patterning of developing structures. Snakes, in particular, have a very elongated trunk and are limbless, representing one of the most extreme morphological adaptations in the vertebrate clade. In this study, we show that the evolution of the snake extreme body plan has been accompanied by major regulatory changes at the HoxD locus while respecting a very conserved global structural constraint.

UNIGE affiliation entities

Citation (ISO format)

GUERREIRO, Isabel. Divergence in Hox gene regulation and the evolution of a snake-like body plan. Doctoral Thesis, 2016. doi: 10.13097/archive-ouverte/unige:84252

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Technical informations

Creation

26/04/2016 18:42:00

First validation

26/04/2016 18:42:00

Update

15/03/2023 00:25:21

Status update

15/03/2023 00:25:21

Last indexation

13/05/2025 17:01:02
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