en
Scientific article
English

Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

Published inJournal of pharmaceutical and biomedical analysis, vol. 21, no. 1, p. 165-174
Publication date1999
Abstract

A simple nonaqueous capillary electrophoresis method is described for the separation of several atropine and scopolamine related drugs. The analysis of these pharmaceutical compounds was performed in a methanol-acetonitrile (25/5, v/v) mixture containing 25 mM ammonium acetate and 1 M acetic acid. The robustness was proved using a full factorial design at two levels. The method was validated and successfully applied for the determination of N-butylscopolamine in different pharmaceutical preparations. Results were compared to those obtained by a capillary electrophoresis method based on aqueous media.

Keywords
  • Butylscopolammonium Bromide/analysis
  • Chemistry, Pharmaceutical
  • Electrophoresis, Capillary/methods
  • Muscarinic Antagonists/analysis
  • Quality Control
  • Reproducibility of Results
Citation (ISO format)
CHERKAOUI, Samir et al. Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations. In: Journal of pharmaceutical and biomedical analysis, 1999, vol. 21, n° 1, p. 165–174. doi: 10.1016/s0731-7085(99)00141-7
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Article (Published version)
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ISSN of the journal0731-7085
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