Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

Cherkaoui, Samir; Mateus, Lidia; Christen, Philippe; Veuthey, Jean-Luc

doi:10.1016/s0731-7085(99)00141-7

Scientific article

English

Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

Contributors

Cherkaoui, Samir; Mateus, Lidia; Christen, Philippe; Veuthey, Jean-Luc

Published in

Journal of pharmaceutical and biomedical analysis, vol. 21, no. 1, p. 165-174

Publication date

1999

Abstract

A simple nonaqueous capillary electrophoresis method is described for the separation of several atropine and scopolamine related drugs. The analysis of these pharmaceutical compounds was performed in a methanol-acetonitrile (25/5, v/v) mixture containing 25 mM ammonium acetate and 1 M acetic acid. The robustness was proved using a full factorial design at two levels. The method was validated and successfully applied for the determination of N-butylscopolamine in different pharmaceutical preparations. Results were compared to those obtained by a capillary electrophoresis method based on aqueous media.

Keywords

Butylscopolammonium Bromide/analysis
Chemistry, Pharmaceutical
Electrophoresis, Capillary/methods
Muscarinic Antagonists/analysis
Quality Control
Reproducibility of Results

UNIGE affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Citation (ISO format)

CHERKAOUI, Samir et al. Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations. In: Journal of pharmaceutical and biomedical analysis, 1999, vol. 21, n° 1, p. 165–174. doi: 10.1016/s0731-7085(99)00141-7

Article (Published version)

Identifiers

PID : unige:8397
DOI : 10.1016/s0731-7085(99)00141-7
PMID : 10701923

Journal ISSN

0731-7085

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22/06/2010 14:24:00

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22/06/2010 14:24:00

Update

14/03/2023 15:49:11

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14/03/2023 15:49:11

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29/10/2024 15:39:45

Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Main files (1)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation