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Title

Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations

Authors
Mateus, Lidia
Published in Journal of Pharmaceutical and Biomedical Analysis. 1999, vol. 21, no. 1, p. 165-74
Abstract A simple nonaqueous capillary electrophoresis method is described for the separation of several atropine and scopolamine related drugs. The analysis of these pharmaceutical compounds was performed in a methanol-acetonitrile (25/5, v/v) mixture containing 25 mM ammonium acetate and 1 M acetic acid. The robustness was proved using a full factorial design at two levels. The method was validated and successfully applied for the determination of N-butylscopolamine in different pharmaceutical preparations. Results were compared to those obtained by a capillary electrophoresis method based on aqueous media.
Keywords Butylscopolammonium Bromide/analysisChemistry, PharmaceuticalElectrophoresis, Capillary/methodsMuscarinic Antagonists/analysisQuality ControlReproducibility of Results
Identifiers
PMID: 10701923
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CHERKAOUI, Samir et al. Nonaqueous versus aqueous capillary electrophoresis for the dosage of N-butylscopolamine in various pharmaceutical formulations. In: Journal of Pharmaceutical and Biomedical Analysis, 1999, vol. 21, n° 1, p. 165-74. https://archive-ouverte.unige.ch/unige:8397

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Deposited on : 2010-06-22

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