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English

New trends in fast liquid chromatography

Contributors

Nguyen, Dao T.-T.; Guillarme, Davy; Rudaz, Serge; Veuthey, Jean-Luc

Published in

Chimia, vol. 61, no. 4, p. 186-189

Publication date

2007

Abstract

Analytical laboratories are currently interested in enhancing overall productivity by increasing sample throughput and reducing analysis time. Different approaches are proposed in liquid chromatography (LC) to perform fast or ultra-fast separations with cycle times of less than 5 or 1 min, respectively. Among these approaches, the use of monolithic supports, high temperature LC (HTLC), short columns and ultra-performance LC (UPLC) are described and compared in this study. A comparison of the above LC approaches is presented through Knox curves and pressure plots based on experimental data. Fast separations of pharmaceutical compounds are presented in order to illustrate the interest of these techniques and compare them with conventional LC separations.

Keywords

  • Fast liquid chromatography
  • HTLC
  • Monolith
  • Short columns
  • UPLC

UNIGE affiliation entities

Citation (ISO format)

NGUYEN, Dao T.-T. et al. New trends in fast liquid chromatography. In: Chimia, 2007, vol. 61, n° 4, p. 186–189. doi: 10.2533/chimia.2007.186

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0009-4293
695views
543downloads

Technical informations

Creation

22/06/2010 11:07:00

First validation

22/06/2010 11:07:00

Update

14/03/2023 15:49:09

Status update

14/03/2023 15:49:08

Last indexation

18/03/2025 09:19:39
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