Doctoral thesis

Lasting effects of reward on declarative memory: behavioral and neural mechanisms in humans

Defense date2016-03-22

I examined the relationship between reward motivation and hippocampus-dependent declarative memory formation. Learning can be modulated by reward through an interaction between the dopaminergic reward circuit and the hippocampus. In 2 experiments on healthy human volunteers, I tested whether memory formation can be enhanced by stretching monetary-reward motivation through processes of memory reactivation and generalization. The first fMRI experiment tested the effect of reward conditioning on hippocampus-dependent learning in a subsequent non-rewarded visuo-spatial learning task. I observed semantic generalization of reward response in the neural reward circuit and a two-fold effect of reward on learning task recall 24h later: memory for associations was impaired but source memory was enhanced for items with a history of high reward. A second behavioral experiment investigated latent effects of reward motivation on associative memory after forgetting. I found lingering effects of initial monetary reward on response confidence, response times and faster relearning.

  • Reward motivation
  • Learning
  • Associative memory
  • Declarative memory
  • VTA-hippocampal loop
  • Dopamine
  • FMRI
  • Relearning
NoteDiplôme commun des univ. de Genève et Lausanne. Thèse en Neurosciences des universités de Genève et de Lausanne
  • Swiss National Science Foundation - n◦ 51NF40-­‐104897
Citation (ISO format)
MIENDLARZEWSKA, Ewa. Lasting effects of reward on declarative memory: behavioral and neural mechanisms in humans. 2016. doi: 10.13097/archive-ouverte/unige:83137
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Creation04/07/2016 1:45:00 PM
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