UNIGE document Doctoral Thesis
previous document  unige:83137  next document
add to browser collection

Lasting effects of reward on declarative memory: behavioral and neural mechanisms in humans

Miendlarzewska, Ewa
Defense Thèse de doctorat : Univ. Genève et Lausanne, 2016 - Neur. 163 - 2016/03/22
Abstract I examined the relationship between reward motivation and hippocampus-dependent declarative memory formation. Learning can be modulated by reward through an interaction between the dopaminergic reward circuit and the hippocampus. In 2 experiments on healthy human volunteers, I tested whether memory formation can be enhanced by stretching monetary-reward motivation through processes of memory reactivation and generalization. The first fMRI experiment tested the effect of reward conditioning on hippocampus-dependent learning in a subsequent non-rewarded visuo-spatial learning task. I observed semantic generalization of reward response in the neural reward circuit and a two-fold effect of reward on learning task recall 24h later: memory for associations was impaired but source memory was enhanced for items with a history of high reward. A second behavioral experiment investigated latent effects of reward motivation on associative memory after forgetting. I found lingering effects of initial monetary reward on response confidence, response times and faster relearning.
Keywords Reward motivationLearningAssociative memoryDeclarative memoryVTA-hippocampal loopDopamineFMRIRelearning
URN: urn:nbn:ch:unige-831371
Note Thèse en Neurosciences des universités de Genève et de Lausanne
Full text
Thesis (4.3 MB) - document accessible for UNIGE members only Limited access to UNIGE
Research group Neuroimagerie du Sommeil et de la Cognition (832)
Swiss National Science Foundation: n◦ 51NF40-­‐104897
(ISO format)
MIENDLARZEWSKA, Ewa. Lasting effects of reward on declarative memory: behavioral and neural mechanisms in humans. Université de Genève. Thèse, 2016. doi: 10.13097/archive-ouverte/unige:83137 https://archive-ouverte.unige.ch/unige:83137

683 hits



Deposited on : 2016-04-18

Export document
Format :
Citation style :