CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

Vuilleumier, Nicolas; Rossier, Michel; Chiappe, Alberto; Degoumois, Florence; Dayer, Pierre; Mermillod, Bernadette; Nicod, Laurent; Desmeules, Jules Alexandre; Hochstrasser, Denis

doi:10.1007/s00228-006-0111-5

Scientific article

English

CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

ContributorsVuilleumier, Nicolas; Rossier, Michel; Chiappe, Alberto; Degoumois, Florence; Dayer, Pierre; Mermillod, Bernadette; Nicod, Laurent; Desmeules, Jules Alexandre; Hochstrasser, Denis

Published inEuropean journal of clinical pharmacology, vol. 62, no. 6, p. 423-429

Collection

Open Access - Licence nationale Springer

Publication date2006

Abstract

To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population.

Keywords

Cosmopolite population
CYP2E1 TaqI polymorphism
Isoniazid-induced hepatitis
NAT2 genotype
Negative predictive value
Positive predictive value

Affiliation entities

Research groups

Auto-immunité, inflammation et athérosclérose (270)

Citation (ISO format)

VUILLEUMIER, Nicolas et al. CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. In: European journal of clinical pharmacology, 2006, vol. 62, n° 6, p. 423–429. doi: 10.1007/s00228-006-0111-5

Article (Published version)

Identifiers

PID : unige:83079
DOI : 10.1007/s00228-006-0111-5
PMID : 16770646

Journal ISSN0031-6970

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CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population.

Technical informations