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Scientific article
Open access
English

CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

Published inEuropean journal of clinical pharmacology, vol. 62, no. 6, p. 423-429
Collection
  • Open Access - Licence nationale Springer
Publication date2006
Abstract

To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population.

Keywords
  • Cosmopolite population
  • CYP2E1 TaqI polymorphism
  • Isoniazid-induced hepatitis
  • NAT2 genotype
  • Negative predictive value
  • Positive predictive value
Citation (ISO format)
VUILLEUMIER, Nicolas et al. CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis. In: European journal of clinical pharmacology, 2006, vol. 62, n° 6, p. 423–429. doi: 10.1007/s00228-006-0111-5
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0031-6970
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315downloads

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