CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis

Article Article scientifique Article CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis eng 2006 author Vuilleumier Nicolas 61406 author Rossier Michel 22435 author Chiappe Alberto author Degoumois Florence 48019 author Dayer Pierre 25460 author Mermillod Bernadette 22748 author Nicod Laurent 22903 author Desmeules Jules Alexandre 73542 author Hochstrasser Denis 26422 423-429 10.1007/s00228-006-0111-5 16770646 0031-6970 To determine whether pharmacogenetic tests such as N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1) genotyping are useful in identifying patients prone to antituberculosis drug-induced hepatotoxicity in a cosmopolite population. Cosmopolite population CYP2E1 TaqI polymorphism Isoniazid-induced hepatitis NAT2 genotype Negative predictive value Positive predictive value Dewey 576 Dewey 615 Open Access - Licence nationale Springer 31 Section des sciences pharmaceutiques 17 136 Département de biologie structurale et bioinformatique 21E false 211 Auto-immunité, inflammation et athérosclérose 270 European journal of clinical pharmacology 62 6 46720623-559f-4983-8561-4bf838b59c50 Article (Published version) Public art%3A10.1007%2Fs00228-006-0111-5.pdf 146297 application/pdf openAccess Faculté des sciences / Section des sciences pharmaceutiques Faculté de médecine / Section de médecine fondamentale / Département de biologie structurale et bioinformatique

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CYP2E1 genotype and isoniazid-induced hepatotoxicity in patients treated for latent tuberculosis	European journal of clinical pharmacology			2006	667	652

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