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Scientific article
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Modulation of osteoblast behavior on TiNxOy coatings by altering the N/O stoichiometry while maintaining a high thrombogenic potential

Published inJournal of biomaterials applications, vol. 30, no. 8, p. 1219-1229
Publication date2016
Abstract

Titanium nitride oxide (TiNxOy) coatings are known to stimulate osteoblast proliferation and osseointegration when compared to microrough titanium implants. The objectives of the present study were to determine whether the beneficial effects of TiNxOy coatings observed with implant osseointegration are dependent on N/O stoichiometry, with the final goal of optimizing these benefits. MMS: TiNxOy coatings with various N/O compositions were deposited on microrough titanium plates (Ti-SLA, 11 × 11 mm). Human primary osteoblast (hOBs) proliferation and gene expression were analyzed for a time course of three weeks, with or without additional stimulation by 1.25 (OH)2 vitamin D3 100 nM. Platelet adhesion/activation and thrombin generation were also assessed.

Citation (ISO format)
MOUSSA, Mira et al. Modulation of osteoblast behavior on TiNxOy coatings by altering the N/O stoichiometry while maintaining a high thrombogenic potential. In: Journal of biomaterials applications, 2016, vol. 30, n° 8, p. 1219–1229. doi: 10.1177/0885328215619084
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ISSN of the journal0885-3282
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