

Other version: http://www.future-science.com/doi/abs/10.4155/bio.14.200
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Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing |
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Published in | Bioanalysis. 2014, vol. 6, no. 19, p. 2523-2536 | |
Abstract | Antidoping procedures are expected to greatly benefit from untargeted metabolomic approaches through the discovery of new biomarkers of prohibited substances abuse. Results: Endogenous steroid metabolites were monitored in urine samples from a controlled elimination study of testosterone undecanoate after ingestion. A platform coupling ultra-high pressure LC with high-resolution quadrupole TOF MS was used and high between-subject metabolic variability was successfully handled using a multiblock data analysis strategy. Links between specific subsets of metabolites and influential genetic polymorphisms of the UGT2B17 enzyme were highlighted. Conclusion: This exploratory metabolomic strategy constitutes a first step toward a better understanding of the underlying patterns driving the high interindividual variability of steroid metabolism. Promising biomarkers were selected for further targeted study. | |
Keywords | Doping analysis — Multiblock data analysis — Steroidomics — Testosterone — UHPLC-QTOF/MS — Urine | |
Identifiers | DOI: 10.4155/bio.14.200 | |
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![]() ![]() Other version: http://www.future-science.com/doi/abs/10.4155/bio.14.200 |
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Research group | Sciences analytiques | |
Citation (ISO format) | BOCCARD, Julien et al. Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing. In: Bioanalysis, 2014, vol. 6, n° 19, p. 2523-2536. https://archive-ouverte.unige.ch/unige:80746 |