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Title

Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing

Authors
Jan, Nicolas
Schweizer, Carine
Pralong, François
Baume, Norbert
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Published in Bioanalysis. 2014, vol. 6, no. 19, p. 2523-2536
Abstract Antidoping procedures are expected to greatly benefit from untargeted metabolomic approaches through the discovery of new biomarkers of prohibited substances abuse. Results: Endogenous steroid metabolites were monitored in urine samples from a controlled elimination study of testosterone undecanoate after ingestion. A platform coupling ultra-high pressure LC with high-resolution quadrupole TOF MS was used and high between-subject metabolic variability was successfully handled using a multiblock data analysis strategy. Links between specific subsets of metabolites and influential genetic polymorphisms of the UGT2B17 enzyme were highlighted. Conclusion: This exploratory metabolomic strategy constitutes a first step toward a better understanding of the underlying patterns driving the high interindividual variability of steroid metabolism. Promising biomarkers were selected for further targeted study.
Keywords Doping analysisMultiblock data analysisSteroidomicsTestosteroneUHPLC-QTOF/MSUrine
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BOCCARD, Julien et al. Untargeted profiling of urinary steroid metabolites after testosterone ingestion: opening new perspectives for antidoping testing. In: Bioanalysis, 2014, vol. 6, n° 19, p. 2523-2536. https://archive-ouverte.unige.ch/unige:80746

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Deposited on : 2016-02-19

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