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Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8

Lau, Kelvin
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Published in BMC plant biology. 2016, vol. 16, no. 1, 42
Abstract Plants perceive UV-B through the UV RESISTANCE LOCUS 8 (UVR8) photoreceptor and UVR8 activation leads to changes in gene expression such as those associated with UV-B acclimation and stress tolerance. Albeit functionally unrelated, UVR8 shows some homology with RCC1 (Regulator of Chromatin Condensation 1) proteins from non-plant organisms at the sequence level. These proteins act as guanine nucleotide exchange factors for Ran GTPases and bind chromatin via histones. Subsequent to the revelation of this sequence homology, evidence was presented showing that UVR8 activity involves interaction with chromatin at the loci of some target genes through histone binding. This suggested a UVR8 mode-of-action intimately and directly linked with gene transcription. However, several aspects of UVR8 chromatin association remained undefined, namely the impact of UV-B on the process and how UVR8 chromatin association related to the transcription factor ELONGATED HYPOCOTYL 5 (HY5), which is important for UV-B signalling and has overlapping chromatin targets. Therefore, we have investigated UVR8 chromatin association in further detail.
PMID: 26864020
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Research groups Groupe Schalch
Groupe Ulm
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BINKERT, Melanie et al. Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8. In: BMC plant biology, 2016, vol. 16, n° 1, p. 42. doi: 10.1186/s12870-016-0732-5 https://archive-ouverte.unige.ch/unige:80719

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Deposited on : 2016-02-17

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