Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8

Article Article scientifique Article Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8 eng 2016 author Binkert Melanie 733790 author Crocco Carlos 809387 author Ekundayo Babatunde 792601 author Lau Kelvin 831683 author Raffelberg Sarah 813153 author Tilbrook Kimberley 742816 author Yin Ruohe 743745 author Chappuis Richard 119993 author Schalch Thomas 787942 author Ulm Roman 0000-0001-8014-7392 732804 42 10.1186/s12870-016-0732-5 26864020 1471-2229 http://bmcplantbiol.biomedcentral.com/articles/10.1186/s12870-016-0732-5 Plants perceive UV-B through the UV RESISTANCE LOCUS 8 (UVR8) photoreceptor and UVR8 activation leads to changes in gene expression such as those associated with UV-B acclimation and stress tolerance. Albeit functionally unrelated, UVR8 shows some homology with RCC1 (Regulator of Chromatin Condensation 1) proteins from non-plant organisms at the sequence level. These proteins act as guanine nucleotide exchange factors for Ran GTPases and bind chromatin via histones. Subsequent to the revelation of this sequence homology, evidence was presented showing that UVR8 activity involves interaction with chromatin at the loci of some target genes through histone binding. This suggested a UVR8 mode-of-action intimately and directly linked with gene transcription. However, several aspects of UVR8 chromatin association remained undefined, namely the impact of UV-B on the process and how UVR8 chromatin association related to the transcription factor ELONGATED HYPOCOTYL 5 (HY5), which is important for UV-B signalling and has overlapping chromatin targets. Therefore, we have investigated UVR8 chromatin association in further detail. Dewey 590 Dewey 580 Dewey 570 23 Institut de génétique et de génomique 0DH 43 Département de biologie moléculaire 161 45 Département des sciences végétales 163 false 815 Groupe Schalch 832 Groupe Ulm BMC plant biology 16 1 56fd543c-8cde-4f0b-939e-bc006302bd76 Article (Published version) Public Binkert_BMCPlantBiol_2016.pdf 2287073 application/pdf CC BY openAccess Centres et instituts / Institut de génétique et de génomique Faculté des sciences / Section de biologie / Département de biologie moléculaire Faculté des sciences / Section de biologie / Département des sciences végétales

Title	Published in	Year	Views	Downloads

Capturing Structural Heterogeneity in Chromatin Fibers	Journal of Molecular Biology	2017	693	777
Structural and biochemical studies on DNA packaging and replication		2017	777	132
Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8	BMC plant biology	2016	619	298

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