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First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates

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Published in Organic Letters. 2007, vol. 9, no. 19, p. 3749-3752
Abstract Chiral amines catalyze the enantioselective conjugate addition of aldehydes to vinyl phosphonates in high yields and with enantioselectivities up to 97% ee. This novel process provides synthetically useful chiral gamma-geminal phosphonate aldehydes which can be easily converted in a few steps into chiral beta-substituted vinyl phosphonates with conservation of the optical purity.
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PMID: 17715930
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SULZER MOSSÉ, Sarah, TISSOT, Matthieu, ALEXAKIS, Alexandre. First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates. In: Organic Letters, 2007, vol. 9, n° 19, p. 3749-3752. https://archive-ouverte.unige.ch/unige:8025

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Deposited on : 2010-06-21

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