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Titles listFirst enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates
Titles listFirst enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates
Scientific Article
unige:8025 
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First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates |
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| Authors | ||
| Published in | Organic Letters. 2007, vol. 9, no. 19, p. 3749-3752 | |
| Abstract | Chiral amines catalyze the enantioselective conjugate addition of aldehydes to vinyl phosphonates in high yields and with enantioselectivities up to 97% ee. This novel process provides synthetically useful chiral gamma-geminal phosphonate aldehydes which can be easily converted in a few steps into chiral beta-substituted vinyl phosphonates with conservation of the optical purity. | |
| Identifiers | DOI: 10.1021/ol7015498 PMID: 17715930 | |
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| Citation (ISO format) | SULZER MOSSÉ, Sarah, TISSOT, Matthieu, ALEXAKIS, Alexandre. First enantioselective organocatalytic conjugate addition of aldehydes to vinyl phosphonates. In: Organic Letters, 2007, vol. 9, n° 19, p. 3749-3752. doi: 10.1021/ol7015498 https://archive-ouverte.unige.ch/unige:8025 |
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