Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

Nakaya, Helder I; Clutterbuck, Elizabeth; Kazmin, Dmitri; Wang, Lili; Cortese, Mario; Bosinger, Steven E; Patel, Nirav B; Zak, Daniel E; Aderem, Alan; Dong, Tao; Del Giudice, Giuseppe; Rappuoli, Rino; Cerundolo, Vincenzo; Pollard, Andrew J; Pulendran, Bali; Siegrist, Claire-Anne

doi:10.1073/pnas.1519690113

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Title		Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood
Authors		Nakaya, Helder I Clutterbuck, Elizabeth Kazmin, Dmitri Wang, Lili Cortese, Mario Bosinger, Steven E Patel, Nirav B Zak, Daniel E Aderem, Alan Dong, Tao Del Giudice, Giuseppe Rappuoli, Rino Cerundolo, Vincenzo Pollard, Andrew J Pulendran, Bali Siegrist, Claire-Anne show all authors [1 - 16]
Published in		Proceedings of the National Academy of Sciences. 2016, vol. 113, no. 7, p. 1853-1858
Abstract		The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells. Compared with transcriptional responses to TIV vaccination previously reported in adults, responses to TIV in infants were markedly attenuated, limited to genes regulating antiviral and antigen presentation pathways, and observed only in a subset of vaccinees. In contrast, transcriptional responses to ATIV boost were more homogenous and robust. Interestingly, a day 1 gene signature characteristic of the innate response (antiviral IFN genes, dendritic cell, and monocyte responses) correlated with hemagglutination at day 28. These findings demonstrate that MF59 enhances the magnitude, kinetics, and consistency of the innate and adaptive response to vaccination with the seasonal influenza vaccine during early childhood, and identify potential molecular correlates of antibody responses.
Identifiers		DOI: 10.1073/pnas.1519690113 PMID: 26755593
Full text		Article (Published version) (1.3 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Centre de Vaccinologie et d'Immunologie néonatale (177)
Citation (ISO format)		NAKAYA, Helder I et al. Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. In: Proceedings of the National Academy of Sciences, 2016, vol. 113, n° 7, p. 1853-1858. doi: 10.1073/pnas.1519690113 https://archive-ouverte.unige.ch/unige:80124