Scientific article
English

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

Publication date2016
Abstract

The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells. Compared with transcriptional responses to TIV vaccination previously reported in adults, responses to TIV in infants were markedly attenuated, limited to genes regulating antiviral and antigen presentation pathways, and observed only in a subset of vaccinees. In contrast, transcriptional responses to ATIV boost were more homogenous and robust. Interestingly, a day 1 gene signature characteristic of the innate response (antiviral IFN genes, dendritic cell, and monocyte responses) correlated with hemagglutination at day 28. These findings demonstrate that MF59 enhances the magnitude, kinetics, and consistency of the innate and adaptive response to vaccination with the seasonal influenza vaccine during early childhood, and identify potential molecular correlates of antibody responses.

Citation (ISO format)
NAKAYA, Helder I et al. Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood. In: Proceedings of the National Academy of Sciences of the United States of America, 2016, vol. 113, n° 7, p. 1853–1858. doi: 10.1073/pnas.1519690113
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0027-8424
622views
2downloads

Technical informations

Creation01/28/2016 9:21:00 AM
First validation01/28/2016 9:21:00 AM
Update time03/15/2023 12:06:38 AM
Status update03/15/2023 12:06:38 AM
Last indexation10/31/2024 2:39:40 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack