Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood

Article Article scientifique Article Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood eng 2016 author Nakaya Helder I author Clutterbuck Elizabeth author Kazmin Dmitri author Wang Lili 696753 author Cortese Mario author Bosinger Steven E author Patel Nirav B author Zak Daniel E author Aderem Alan author Dong Tao author Del Giudice Giuseppe 22937 author Rappuoli Rino author Cerundolo Vincenzo author Pollard Andrew J author Pulendran Bali author Siegrist Claire-Anne 26816 1853-1858 10.1073/pnas.1519690113 26755593 0027-8424 The dynamics and molecular mechanisms underlying vaccine immunity in early childhood remain poorly understood. Here we applied systems approaches to investigate the innate and adaptive responses to trivalent inactivated influenza vaccine (TIV) and MF59-adjuvanted TIV (ATIV) in 90 14- to 24-mo-old healthy children. MF59 enhanced the magnitude and kinetics of serum antibody titers following vaccination, and induced a greater frequency of vaccine specific, multicytokine-producing CD4(+) T cells. Compared with transcriptional responses to TIV vaccination previously reported in adults, responses to TIV in infants were markedly attenuated, limited to genes regulating antiviral and antigen presentation pathways, and observed only in a subset of vaccinees. In contrast, transcriptional responses to ATIV boost were more homogenous and robust. Interestingly, a day 1 gene signature characteristic of the innate response (antiviral IFN genes, dendritic cell, and monocyte responses) correlated with hemagglutination at day 28. These findings demonstrate that MF59 enhances the magnitude, kinetics, and consistency of the innate and adaptive response to vaccination with the seasonal influenza vaccine during early childhood, and identify potential molecular correlates of antibody responses. Dewey 616.07 137 Département de pathologie et immunologie 21F false 143 Centre de Vaccinologie et d'Immunologie néonatale 177 Proceedings of the National Academy of Sciences of the United States of America 113 7 6dd4d63b-ab4c-416d-bb65-41ac1daf2ad9 Article (Published version) Restricted PNAS-2016-Nakaya-1519690113.pdf 1414906 application/pdf restrictedAccess Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie

Title	Published in	Access level	OA Policy	Year	Views	Downloads

Systems biology of immunity to MF59-adjuvanted versus nonadjuvanted trivalent seasonal influenza vaccines in early childhood	Proceedings of the National Academy of Sciences of the United States of America			2016	658	2

Archive ouverte UNIGE

Wang, Lili