Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy

Pagnoux, Christian; Quéméneur, Thomas; Ninet, Jacques; Diot, Elisabeth; Kyndt, Xavier; de Wazières, Benoît; Reny, Jean-Luc; Puéchal, Xavier; le Berruyer, Pierre-Yves; Lidove, Olivier; Vanhille, Philippe; Godmer, Pascal; Fain, Olivier; Blockmans, Daniel; Bienvenu, Boris; Rollot, Florence; Aït el Ghaz-Poignant, Séverine; Mahr, Alfred; Cohen, Pascal; Mouthon, Luc; Perrodeau, Elodie; Ravaud, Philippe; Guillevin, Loïc; French Vasculitis Study Group

doi:10.1002/art.39011

Scientific article

English

Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy

Published inArthritis & rheumatology, vol. 67, no. 4, p. 1117-1127

Publication date2015

Abstract

To investigate a new therapeutic strategy, with rapid corticosteroid dose tapering and limited cyclophosphamide (CYC) exposure, for older patients with systemic necrotizing vasculitides (SNVs; polyarteritis nodosa [PAN], granulomatosis with polyangiitis [Wegnener's] [GPA], microscopic polyangiitis [MPA], or eosinophilic GPA [Churg-Strauss] [EGPA]).

Keywords

Adrenal Cortex Hormones/therapeutic use
Aged
Aged, 80 and over
Azathioprine/therapeutic use
Cyclophosphamide/therapeutic use
Drug Administration Schedule
Drug Therapy, Combination
Female
Humans
Male
Methotrexate/therapeutic use
Remission Induction/methods
Systemic Vasculitis/drug therapy
Treatment Outcome

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie

Research groups

Plaquettes et antithrombotiques (13)

Citation (ISO format)

PAGNOUX, Christian et al. Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy. In: Arthritis & rheumatology, 2015, vol. 67, n° 4, p. 1117–1127. doi: 10.1002/art.39011

Article (Published version)

Identifiers

PID : unige:79659
DOI : 10.1002/art.39011
PMID : 25693055

Journal ISSN2326-5191

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Creation11/17/2015 4:17:00 PM

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Treatment of systemic necrotizing vasculitides in patients aged sixty-five years or older: results of a multicenter, open-label, randomized controlled trial of corticosteroid and cyclophosphamide-based induction therapy

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